Cre Mouse & Rat Models | Biocytogen

Cre mice express Cre recombinase under the control of a tissue specific gene promoter, i.e. Cre mouse lines provide the tissue specificity of gene editing. If ... Researchersusegene-editedmousemodelstostudygeneexpression,investigategeneticdiseases,conductpreclinicaldrugefficacytestsandmore.Inmanystudies,amousemodelexpressesagenemutationthroughoutitsdevelopmentandlife,necessitatinganinduciblediseasemousemodelwhenresearchersneedmorecontrolovergeneexpression. Mousemodelsthatprovidethislevelofcontrolarecalledconditionalmousemodels,ofwhichoneofthemosteffectiveistheCre/Loxpmouse.CremiceexpressCrerecombinaseunderthecontrolofatissuespecificgenepromoter,i.e.Cremouselinesprovidethetissuespecificityofgeneediting.IfCreERT2insteadofCreisused,thentheDNArecombinaseactivityisinducedbyTamoxifen,sothattheCre/Loxpmousemodelwillbeconditionalandinducible.TheLoxPmouselinehastwoloxPelementsflankingtheentireorpartofthegeneofinterest,givingtheloxPmousedefinedgene(s)tobeedited. TheCre-Loxsystemisanefficientmethodforproducingconditionalmousemodels.AtBiocytogen,weprovidecustomCre-Loxmousemodelsforuseinacademicandpharmaceuticalresearch.WecandesignaCremousemodel,conductresearchanddeliverresultsinaslittleasninemonths.Filloutaformorcontactustodaytolearnmore. CreMouseModelsList Product ProductNo ApplicationFields B-CAG-iCreERT2mice 110147 Functionresearchofgenes,Systemicknockoutoflethaltargetgenesinembryos B-CAG-tdTomatocKImice 110148 Cre-inducedtdTomatoexpressionforCreexpressionprofiledetection B-Cdh5-iCreERT2mice 110140 Cdh5promoter-driveninducibleCremousemodel(lungadult,subcutaneousfatpadadult) B-Epor-EGFP-iCremice 110880 Functionresearchofgenes, Functionresearchoferythrocytes B-Gfap-iCremice 110144 Gfappromoter-drivenCremousemodel.(Astroglia) B-Grpr-iCreMice 110125 Grprpromoter-drivenCremousemodel(digestivesystem,nervoussystem) B-Nkp46-iCremice 110127 Ncr1promoter-drivenCremousemodel(NKcell) B-Pdgfrb-iCreMice 110129 Pdgfrbpromoter-driveninducibleCremousemodel(parietalcellofmultipleorgans,suchasskin,intestinaltract,kidney,lungandplexusvasculosusaroundcentralnervoussystem) B-Prrx1-iCreMice 110130 Prrx1promoter-drivenCremousemodel(mesenchyme) B-Sp7-iCremice 110131 Sp7promoter-drivenCremousemodel(skeleton) B-Tcf21-iCreERT2mice 110141 Tcf21promoter-driveninducibleCremousemodel(bladder,lung) B-Ucp1-iCreMice 110134 UCP1promoter-drivenCremousemodel(mitochondria,brownfat) CreRatModelsList Product ProductNo ApplicationFields B-CAG-iCrerats 211350 Creubiquitousexpressioninrats B-Drd2-CreRats 210488 Drd2promoter-drivenCreratmodel(nucleusaccumbens,dorsalstriatum,pituitary) B-Oxt-iCrerats 210501 Oxt promoter-drivenCreratmodel(hypothalamus;) RequestaQuote FirstName* LastName* Company/Institution* Email* Telephone ProductName* Country* 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State* ModelCategory* HumanizedImmune-CheckpointMiceImmunodeficientMiceHumanizedTumorCellLinesLuciferaseTumorCellLinesCreMouse/RatModelsHumanizedCytokinesMiceOthers Message RelatedResources Events Webinar:PreclinicalModelstoInvestigateNKCell-TargetedImmunotherapies| August04,2022 10thannualImmuno-OncologySummit| August02,2022 18thInternationalSCBASymposium| July26,2022 BasicCardiovascularSciencesScientificSessions2022| July19,2022 TumorModelsBoston2022| June09,2022 EACR2022Congress| June07,2022 News BiocytogenListsontheMainBoardofHKEX,AimingtoBecometheHeadstreamofNewDrugs| September01,2022 USFDAApprovalofINDforCTLA-4AntibodyYH001fortheTreatmentofFront-lineSarcomaPatientsinCombinationwithEnvafolimab| August30,2022 BiocytogenExpandsPartnershipwithMerck| August25,2022 BiocytogenandLiberoTheraAchieveMilestoneProgressinCo-DevelopmentofFullyHumanGPCRAntibodyDrugs| July21,2022 Biocytogen/EucureBiopharmaAnnounceFirstPatientDosedinPhaseIIClinicalTrialofYH003CombinationTherapyasaFirst-LineTreatmentforMucosalMelanoma| July12,2022 BiocytogenEuropeInnovationCenterTeamtoPresentatAET-EU2022,IntroducingProjectIntegrum,TCR-mimicPlatformandYH012| June03,2022 RequestaQuote FirstName* LastName* Company/Institution* Email* Telephone ProductName* Country* 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State* ModelCategory* HumanizedImmune-CheckpointMiceImmunodeficientMiceHumanizedTumorCellLinesLuciferaseTumorCellLinesCreMouse/RatModelsHumanizedCytokinesMiceOthers Message Pleasebeawareyou'releavingBioCytogen'swebsite.Byclicking"Continue"below,youwillberedirectedtothefollowingthirdpartysite:.BioCytogenisnotresponsiblefortheinformationfoundonthissiteandthissiteisprovidedasaninformationalsourceonly. 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