斑馬魚端腦在空間記憶上所扮演的角色

壹、中文摘要記憶會以多元方式於大腦神經細胞中形成及儲存，並可因應需求而重新喚回及 ... 不論是長期或短期的空間記憶形成，皆需要端腦腦區（telencephalon）的參與。

4. 資料載入處理中... 跳到主要內容 臺灣博碩士論文加值系統 ::: 網站導覽| 首頁| 關於本站| 聯絡我們| 國圖首頁| 常見問題| 操作說明 English |FB專頁 |Mobile 免費會員 登入| 註冊 功能切換導覽列 (165.22.106.144)您好！臺灣時間：2022/05/2806:14 字體大小：       ::: 詳目顯示 recordfocus 第1筆/ 共1筆  /1頁 論文基本資料 摘要 外文摘要 目次 參考文獻 電子全文 紙本論文 QRCode 本論文永久網址: 複製永久網址Twitter研究生:吳世郁研究生(外文):Shih-YuWu論文名稱:斑馬魚端腦在空間記憶上所扮演的角色論文名稱(外文):Toelucidatethepossibleroleoftelencephalonontheformationofspatialmemoryinzebrafish指導教授:呂國棟指導教授(外文):Kwok-TungLuPh.D.學位類別:碩士校院名稱:國立臺灣師範大學系所名稱:生命科學研究所學門:生命科學學門學類:生物學類論文種類:學術論文論文出版年:2008畢業學年度:96語文別:中文論文頁數:69中文關鍵詞:情境線索、長期記憶、長期增益、端腦旁側腦區、N-甲基-D-天冬胺酸、端腦中側腦區、顳葉中側、短期記憶外文關鍵詞:CPP、conditionedplacepreference、LTM、long-termmemory、LTP、long-termpotentiation、LP、telencephaliclateralpallia、NMDA、N-methyl-D-aspartate、MP、telencephalicmedialpallia、MTL、medialtemporallobe、STM、short-termmemory相關次數: 被引用:3點閱:508評分:下載:54書目收藏:0 壹、中文摘要記憶會以多元方式於大腦神經細胞中形成及儲存，並可因應需求而重新喚回及表現已儲存之記憶。

海馬迴為哺乳類與大部分陸地脊椎動物腦內，與空間記憶有關之重要腦區。

實驗證實硬骨魚的端腦同源於哺乳類的海馬迴，負責空間相關之學習與記憶等認知功能。

本研究採用改良型之斑馬魚T字形迷宮，合併學習前或學習後之端腦破壞處理，以探討斑馬魚之端腦與空間記憶之關聯，及其在記憶習得（acquisition）、保存（retention）與提取（retrieval）過程中的重要性。

實驗結果顯示，1.雙側端腦破壞不會影響斑馬魚的自發性探索行為，卻會明顯干擾空間記憶的習得、保存與表現。

2.學習前的雙側端腦破壞，會同時影響長期記憶，及短期記憶的獲取與表現。

3.學習後的雙側端腦破壞，會破壞先前已建立之空間記憶，顯示不論是長期或短期的空間記憶形成，皆需要端腦腦區（telencephalon）的參與。

4.此外，學習後的左側端腦破壞，使斑馬魚無法正常表現先前已建立之空間記憶。

5.學習前右側端腦破壞，使斑馬魚出現空間記憶學習障礙。

這些結果顯示，左、右端腦半球在空間記憶形成過程中，具有功能上的不對稱性。

使左、右端腦分別在空間的學習與記憶上，具有不同程度的優勢性。

綜合以上各點，本研究證實端腦在斑馬魚空間學習與記憶上扮演重要的角色，且參與層面廣涵空間記憶的習得、保存、提取與表現。

此外，初步證實斑馬魚端腦左、右側可能與哺乳類相似具有空間定位優勢性。

此結果不但可作為與其他物種在神經生理學上及演化的比較，且有助斑馬魚模式於神經科學研究應用之推廣。

貳、英文摘要AbstractMemorywhichstoresanddealswithallrequirementsofexistenceisformedinvariouswaysinthenervecellsofthebrain.Hippocampusiscriticalfortheformationofspatialmemoryinmammalsandlandvertebrates.Thetelencephaloninteleostfishishomologoustothehippocampusofmammalian,whichisspecificallyinvolvedinspatiallearningandmemory.Thepresentstudywasaimedtostudypossibleroleoftelencephalononthespatiallearningandmemoryinzebrafish.Whichincludetheimportanceoftelencephalonontheacquisition,retention,andretrievalofspatialmemories.Toachievethisgoal,weusedmodifiedT-mazeparadigmcombinedwithspecificlesionoftelencephalonbeforeandafterspatiallearning.Resultsshowed:1.Eitherglobalorunilaterallesionofthetelencephalonhasnoimpactsforlocomotoractivitybutdeficittheacquisition,retentionandretrievalofspatialmemory.2.Lesionofthetelencephalonimpairsnotonlythelong-termbutalsotheshort-termmemory.3.Functionalasymmetricoftelencephalononspatiallearninghasbeenfoundinzebrafish.4.Rightsidetelencephalonisdominantforthespatiallearningandmemory.Accordingtoourresults,weconcludedthattelencephalonplaysavitalroleofspatiallearningandmemoryinzebrafishontheacquisition,retention,andretrievalofspatialmemory.Thetelencephalonofzebrafishhascerebrallateralizationwhichissimilartomammals.Theresultsgatheringfromthisstudycanbeappliedtothecomparativeneurophysiologicalstudiesbetweendifferentspecies.Butalsoextendtheusageofzebrafishmodelonneuroscienceresearch. 壹、中文摘要0貳、英文摘要ABSTRACT3參、緒論5一、研究背景（STUDYBACKGROUND）5A.學習與記憶（LEARNINGANDMEMORY）5B.空間記憶（SPATIALMEMORY）9C.硬骨魚的學習與記憶（LEARNINGANDMEMORYINTELEOSTFISH）12D.斑馬魚（ZEBRAFISH）15二、研究目的（STUDYPURPOSES）19肆、研究材料與方法19A.實驗動物（ANIMALS）20B.行為試驗儀器（APPARATUS）20C.空間訓練程序（BEHAVIORPROCEDURE）21D.端腦手術（SURGERY）24E.腦部組織破壞程度檢定（REPRESENTATIONOFBRAIN）25F.統計方法（STATISTICS）。

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