NF-kB Target Genes » NF-kB Transcription Factors - Boston ...

(*indicates that the gene has a kB site in the promoter but has not clearly been shown to be controlled by NF-kB; or the gene expression is associated with ... LatestCOVID-19Information ThisSiteBUMedicalAllBUBUMapsBUDirectoryGoogle TheGilmoreLab NF-kBTranscriptionFactorsHome TheLab PeopleoftheLab GilmoreLabPublications GeneResources NF-kBTargetGenes cDNASequences MouseGeneKnockouts HumanGenes ProteinStructures PhysiologicalMediators Protein-ProteinInteractions NF-kBInducers NF-kBInhibitors Diseases OtherResources References RelatedLinks Reagents News News ContactUs NF-kBTargetGenes TargetGenesofNF-kB Cytokines/ChemokinesandtheirModulators Immunoreceptors ProteinsInvolvedinAntigenPresentation CellAdhesionMolecules AcutePhaseProteins StressResponseGenes CellSurfaceReceptors RegulatorsofApoptosis GrowthFactors,LigandsandtheirModulators EarlyResponseGenes TranscriptionFactorsandRegulators Viruses Enzymes Miscellaneous (*indicatesthatthegenehasakBsiteinthepromoterbuthasnotclearlybeenshowntobecontrolledbyNF-kB;orthegeneexpressionisassociatedwithincreasedNF-kBactivitybuthasnotbeenshowntobeatargetdirectly) Cytokines/Chemokinesandtheirmodulators Gene Function Reference Acc# HumanGeneName BAFF B-cellActivatingFactor Moon&Park,2007 NM_006573 TNFSF13B BLIMP-1 Blymphocyte-inducedmaturationprotein-1 Calame,2008 NM_00198 BLIMP1/PRDM1 CCL5 T-cellsecretedfactor Wickremasingheetal,2004 NM_002985 CCL5 CCL15/Leukotactin/SCYA15 Chemokineforcellattraction Shinetal,2005 NM_032965 CCL15 CCL17 Chemokine Takegawaetal,2008 NM_002987 CCL17 CCL19 RecruitmentofnaiveTcellstodendriticcells Pietilaetal,2007 NM_006274 CCL19 CCL20 LigandofCCchemokinereceptor6 Leeetal,2008;Battagliaetal,2007 NM_004591 CCL20 CCL22 Epithelialcellchemokineatmucosa Nakayamaetal,2004 NM_002990 CCL22 CCL23/SYA23 Monocytechemokine Shinetal,2007 NM_005064 CCL23 CCL28 ChemokineforT-cellattraction Ogawaetal,2004 NM_148672 CCL28 CINC-1 Cytokine-inducedneutrophilchemoattractant Blackwelletal,1994Ohtsukaetal,1996 NM_001511 CXCL1 *CXCL11 ChemokineligandforCXCR3 Tensenetal,1999 NM_005409 CXCL11 Eotaxin betaChemokine,eosinphil-specific Heinetal,1997 NM_001565. CXCL10 Fractalkine TNF-inducedchemokine Ahnetal,2004;Bhavsaretal,2008 NP_002987 CXCL3 Groalpha Melanomagrowthstimulatingactivity Anisowiczetal,1991 NM_001511 CXCL1 Grobeta Chemokine Anisowiczetal,1991 AAP13104 GRO-beta Grogamma Chemokine Anisowiczetal,1991 AAP13105. GRO-gamma Gro-1 Growthregulatedoncogene;chemokine Wood,1995 NM_001511 CXCL1 *ICOS Inducibleco-stimulator HaaningAndersonetal,2003 NM_012092 ICOS IFN-g Interferon Sicaetal,1992;Sicaetal,1997 NM_000619 IFNG IL-1a Interleukin-1a Mori&Prager,1996 NM_000575 IL1A IL-1b Interleukin-1b Hiscottetal,1993 NM_000576 IL1B IL-1receptorantagonist InhibitorofIL-1activity Smithetal,1994 NM_173842 IL1RN IL-2 Interleukin-2 Serflingetal,1989;Hoyosetal,1989;Laietal,1995 NM_000586 IL2 IL-6 Interleukin-6,inflammatorycytokine Libermann&Baltimore,1990;Shimizuetal,1990;Sonetal,2008 NM_000600 IL6 IL-8 Interleukin-8,alpha-chemokine Kunsch&Rosen,1993;Kangetal.,2007 NM_000584 IL8 IL-9 Interleukin-9 Zhuetal,1996;Chenetal,2008 NM_000590 IL9 IL-10 Interleukin-10 Xu&Shu,2002;Caoetal,2006 NM_000572 IL10 IL-11 Interleukin-11 Bitkoetal,1997 NM_000641 IL11 IL-12B(p40) Interleukin-12 Murphyetal,1995 NM_002187 IL12B IL-12A(p35) Interleukin-12 Hommaetal,2007 NM_000882 IL12A IL-13 Interleukin-13 Hinzetal,2002 NM_002188 IL13 *IL-15 Interleukin-15 Azimietal,1998 NM_172174 IL15 IL-17 Interleukin-17 Shenetal,2006 NM_002190 IL17 IL-23A(p19) Interleukin-23(p19gene) Carmodyetal,2006;Liuetal,2007 NM_016584 IL23A IL-27(p28) Interleukin-27(p28subunit) Liuetal,2007 NM_145659 IL27 EBI3/IL-27B EBV-inducedgene3(IL-27betachain) Poleganovetal,2008 NM_005755 EBI3 beta-Interferon Interferon Hiscottetal,1989; NM_002176 IFNB1 Lenardoetal,1989 IP-10 alphaChemokine Ohmori&Hamilton,1993;Yangetal,2007 NM_002994 CXCL5 KC alphaChemokine Ohmorietal,1995 S79767 KC IiGp1 Cytokine Buntingetal,2007 NM_021792 Iigp1 NM_002994 CXCL5 *LIX(mouse);ENA-78(CXCL5)andGCP-2(CXCL6)(human) LPS-inducedCXCchemokines Smithetal,2002 NM_002993 CXCL6 Lymphotoxina TNF-likecytokine Wormetal,1998 NM_000595 LTA Lymphotoxinb AnchorsTNFtocellsurface Kuprashetal,1996 NM_002341 LTB MCP-1/JE Macrophagechemotacticprotein,betaChemokine Uedaetal,1994;Uedaetal,1997 NM_002982 CCL2 Teferedegneetal,2006;Xing&Remick,2007;Ishikadoetal,2009 MIG MonokineinducedbyIFN-gamma Buntingetal,2007 NM_002416 CXCL9 MIP-1a,b Macrophageinflammatoryprotein-1,bChemokine Grove&Plumb,1993;Widmeretal,1993 NM_002983 CCL3 NM_002984 CCL4 aka(LAG-1) Lymphocyteactivationgene-1 Xuetal,2002;Modietal,2001 NM_002984 CCL4 MIP-2 Macrophageinflammatoryprotein-2,bChemokine Widmeretal,1993;Leeetal,2005 NM_002090 CXCL3 MIP-3alpha/CCL20 Macrophageinflammatoryprotein-3a Kwonetal,2002;Tomimorietal,2007 NM_004591 CCL20 *mob-1 AC-X-Cchemokine Varleyetal,2003 NM_001565 CXCL10 Neutrophilactivatingpeptide-78 Activatesneutrophils Keatesetal.,2001 NM_002994 CXCL5 RANTES RegulateduponActivationNormalTlymphocyteExpressedandSecreted,bChemokine Moriuchietal,1997 NM_002985 CCL5 TCA3,T-cellactivationgene3 T-cellactivationgene3,betachemokine Oh&Metcalfe,1994 NM_002981 CCL1 TNFalpha Tumornecrosisfactoralpha Shakhovetal,1990;Collartetal,1990 NM_000594 TNF TNFbeta Tumornecrosisfactorbeta Pauletal,1990;Messeretal,1990 NM_000595 LTA TRAIL(akaApo2ligand) Cytokine Baetuetal,2001;Matsudaetal,2005 NM_003810 TNFSF10 TFF3(Treefoilfactor) Peptideinresponsetogutirritation Baus-Loncaretal,2004 NM_003226 TFF3 VEGI Vascularendothelialgrowthinhibitor Xiaoetal,2005 NM_005118 TNFSF15 Immunoreceptors Gene Function Reference Access# HumanGeneName B7.1(CD80) Co-stimulationofTcellsviaCD28binding Fongetal,1996;Zhaoetal,1996 NM_005191 CD80 BRL-1 B-cellhomingreceptor Wolfetal,1998 NM_001716 BLR1 CCR5 Chemokinereceptor Liuetal,1998 NM_000579 CCR5 CCR7 Chemokinereceptor Hopkenetal,2002 NM_001838 CCR7 CXCR Chemokinereceptor Maxwelletal,2007 NM_000634 IL8RA CXCR2 Chemokinereceptor Maxwelletal,2007 NM_001557 IL8RB CD137 TNF-likereceptor Kimetal,2003 NM_001561 TNFRSF9 CD154 CD40ligand Srahnaetal,2001;Schubertetal,2002;Phametal,2005 NM_000074 CD40LG CD3gamma T-cellmarker Willard-Galloetal,2005 NM_000073 CD3G CD21 B-cellsurfacemolecule Debnathetal,2007 NM_001006658 CR2 CD38 NADtocADPriboseconvertingmolecule Kangetal,2006;Tirumurugaanetal,2008 NM_001775 CD38 CD40 TNF-receptorfamilymember Hinzetal,2001 NM_001250 CD40 CD48 Antigenofstimulatedlymphocytes Klaman&Thorley-Lawson,1995 NM_001778 CD48 CD83 T-celldevelopmentmolecule McKinseyetal,2000;Berchtoldetal,2002 NM_004233 CD83 CD86 Dendriticcelldevelopmentmolecule Zou&Hu,2005 NM_175862 CD86 CD98 Membranereceptor,survivalbloodcells Yanetal,2006 NM_001012661 SLC3A2 CD134 TNF-likereceptor Toneetal,2007 NM_003327 TNFRSF4 *F11-receptor Ig-likereceptorforplateletadhesion Sobockietal,2005 NM_016946 F11R FcRn NeonatalreceptorforIgG Liuetal,2007 NM_004107 FCGRT FcepsilonreceptorII(CD23) ReceptorforIgE Richards&Katz,1997;Luetal,2006;Debnathetal,2007 NM_002002 FCER2 HLA-G Humanleukocyteantigen-G Langatetal.,2007 NM_002127 HLA-G *ICOS T-cellactivationfactor Shillingetal.,2005 NM_012092 ICOS IL-2receptora-chain IL-2receptorsubunit Ballardetal.,1988 NM_000417 IL2RA ImmunoglobulinCgamma1 IgGheavychain Lin&Stavnezer,1996 J00230 IGHG2 Immunoglobulingamma1 IgGheavychain Dryer&Covey,2005 J00228 IGHG1 Immunoglobulingamma4 IgGheavychain Agresti&Vercelli,2002 K01316 IGHG4 Immunoglobulineheavychain IgEheavychain Icieketal,1997 J00222 IGHE Immunoglobulinklightchain Antibodylightchain Sen&Baltimore,1986 J00241 IGKC InvariantChainII Antigenpresentation Pessara&Koch,1990 KininB1Receptor Cardiovascularhomeostasis;inflammation Merinoetal,2005 NM_000710 BDKRB1 MHCclassI(H-2Kb) Majorhistocompatibilityantigen Israëletal,1989a;Israëletal,1989b MHCClassIHLA-B7 Majorhistocompatibilityantigen Johnson&Pober,1994 NM_005514 HLA-B b2Microglobulin ChaperoneforMHCclassI-likemolecules Israëletal,1989a;Israëletal,1989b;Gobinetal,2002 NM_004048 B2M Nod2 Intracellularpathogenrecognition Gutierrezetal,2002 NM_022162 NOD2 PolymericIgreceptor BindsIg Schjervenetal,2001 AJ276452 pIgR PGRP-S Peptidoglycanrecognitionprotein-S Langetal,2007 NM_005091 PGLYRP1 T-cellreceptorbchain T-cellreceptorsubunit Jamiesonetal,1989;McMillan&SIkes,2008 NG_001333 TCRB T-cellreceptor/CD3gamma T-cellreceptorsubunit Badranetal,2002 NM_000073 CD3G TLR-2 Toll-likereceptor Wangetal,2001;Johnson&Tapping,2007 NM_003264 TLR2 TLR9 Toll-likereceptor Takeshitaetal,2004 NM_017442 TLR9 *TNF-Receptor,p75/80(CD120B) High-affinityTNFreceptor Santee&Owen-Schaub,1996 NM_001066 TNFRSF1B TREM-1 Neutrophil/monocyteIgreceptor Zengetal,2007 NM_018643 TREM1 Proteinsinvolvedinantigenpresentation Gene Function Reference Acc# HumanGeneName ComplementB Activatorofalternativecomplementpathway Huangetal,2002 NM_001710 CFB Complementcomponent3 Componentofcomplementpathway Moonetal,1999 NM_000064 C3 ComplementReceptor2 ComplementreceptorforB-cellresponsetoAg Tolnayetal,2002 NM_001006658 CR2 ProteasomeSubunitLMP2 Subunitof26Sproteasome,cysteineprotease Wrightetal,1995;Marquesetal,2004 NM_002800 PSMB9 PeptideTransporterTAP1 PeptidetransporterforER Wrightetal,1995;Marquesetal,2004 NM_000593 TAP1 Tapasin MHCclassIpresentationandassembly Herrmannetal,2003 NM_003190 TAPBP Celladhesionmolecules Gene Function Reference Acc# HumanGeneName CD44 Cell-surfacereceptorforhyaluronicacid Hinzetal,2002 NP_000601 CD44 DC-SIGN DendriticcellsurfaceC-typelectin Liuetal,2003 NM_021155 CD209 ELAM-1(CD62E,E-selectin) E-selectin,endothelialcellleukocyteadhesionmolecule Whelanetal,1991;Schindler&Baichwal,1994 NM_000450 SELE Endoglin Endothelialcellmembraneglycoprotein Botellaetal,2002 NM_000118 ENG Fibronectin Extracellularattachment Leeetal,2002;Nortonetal,2004 NM_002026 FN1 ICAM-1 Intercellularadhesionmolecule-1 vandeStolpeetal.,1994;Buntingetal,2007 NM_000201 CD54 MadCAM-1 Mucosaladdressincelladhesionmolecule Takeuchi&Baichwal,1995 NM_130760 MADCAM1 NCAM Neuralcelladhesionmolecule Simpson&Morris,2000 NM_000615 NCAM P-selectin Plateletadhesionreceptor Pan&McEver,1995 NM_003005 SELP Tenascin-C ECMproteincontrolscellattachmentandmigration,cellgrowth Mettouchietal,1997 NM_002160 TNC VCAM-1 Vascularcelladhesionmolecule Iademarcoetal,1992 NM_001078 VCAM1 Acutephaseproteins Gene Function Reference Acc# HumanGeneName Angiotensinogen(AngiotensinII) Angiotensinprecursor,regulatesbloodpressure Brasieretal,1990;Ronetal,1990 NM_000029 AGT beta-defensin-2 Anti-microbialpeptide Diamondetal,2000;Tsutsumi-Ishii&Nagaoka,2002;Kaoetal,2008 AF040153 DEFB2 C4bbindingprotein Complementbindingprotein Moffat&Tack,1992 NM_000715 C4BPA ComplementfactorB Complementfactor Nonaka&Huang,1990 NM_001710 CFB ComplementfactorC4 Activatesextrinsicpathwayofcomplementactivation Yuetal,1989 NM_007293 C4A C-reactiveprotein Hostdefenseprotein Zhangetal,1995;Agrawaletal,2003a Agrawaletal,2003b NM_000567 CRP Hepcidin Acutephaseprotein Liaoetal,2006 NM_021175 HAMP Lipopolysaccharidebindingprotein BindstoLPSreceptor(CD14)withLPS Schumann,1995 NM_004139 LBP PentraxinPTX3 Pentraxin Basileetal,1997 NM_002852 PTX3 SerumamyloidAproteins(SAA1,SAA2,SAA3) Serumcomponents Edbrookeetal,1991;Li&Liao,1991;Thorn&Whitehead,2002;Sonetal,2004 NM_000331 SAA1 SerumamyloidAproteins(SAA1,SAA2,SAA3) Serumcomponents NM_030754 SAA2 SerumamyloidAproteins(SAA1,SAA2,SAA3) Serumcomponents S73444 SAA3 Tissuefactor-1 Activatesextrinsicpathwayofcomplementactivation Mackmanetal,1991 NM_001993 F3 Urokinase-typeplasminogenactivator Activatesfibrinogenforfibrinclotlysis Novaketal,1991 NM_002658 PLAU Stressresponsegenes Gene Function Reference Acc# HumanGeneName *CYP2E1 Cytochromep450 Abdel-Razaketal,2004 NM_000773 CYP2E1 CYP2C11 Cytochromep450 Morganetal,2002 X79081 CYP2C11 CYP7b Cytochromep450 Dulosetal,2005 NM_004820 CYP7B1 COX-2 Cyclooxygenase,prostaglandinendoperoxidesynthase Yamamotoetal,1995;Ackermanetal,2008;Kaltschmidtetal,2002 NM_000963 PTGS2 FerritinHchain Ironstorageprotein Kwaketal,1995 NM_002032 FTH1 Glutamate-cysteineligase GSHbiosynthesis Pengetal,2010 GCLC Glutamate-cysteineligasemodifier GCLCmodifierprotein Pengetal,2010 GCLM HSP90-alpha Heatshockprotein Ammiranteetal,2007 NM_001017963 HSP90AA1 *5-Lipoxygenase(guineapig) Arachidonicacidmetabolicenzyme,leukotrienesynthesis Chopraetal,1992 XM_001127464 ALOX5 12-Lipoxygenase Arachidonicacidmetabolicenzyme Arakawaetal,1995 NM_000697 ALOX12 InducibleNO-Synthase NOsynthesis Gelleretal,1993 NM_000625 NOS2A *MAP4K1 Activatorofstress-inducedproteinkinasepathway Carteretal,2002 NM_001042600 MAP4K1 SENP2 SUMO-specificprotease SMiyamoto,perscommun NC_0000013.10 SENP2 Cu/ZnSOD Superoxidedismutase Rojoetal,2004 NM_000454 SOD1 SOD1 Manganeseuperoxidedismutase Dasetal,1995 NM_000454 SOD1 SOD2 Manganesesuperoxidedismutase Xuetal,1999a;1991b;2007a;2007b NM_000636 SOD2 *Mx1 Viralresistancegene Gerardinetal,2004 NM_002462 MX1 NAD(P)Hquinoneoxidoreductase(DT-diaphorase) Bioreductiveenzyme Yao&O’Dwyer,1995 NM_000903 NQO1 PhospholipaseA2 Fattyacidmetabolism Morrietal,1994 AF058921 PLA2 SEPS1 Involvedincytokineproduction Gaoetal,2006 NM_018445 SELS Cell-surfacereceptors Gene Function Reference Acc# HumanGeneName ABCA1 ATP-bindingcassettetransporter Gerbod-Giannoneetal,2006 NM_005502 ABCA1 ABCC6 ATP-binding,multidrugresistance-associatedprotein6transporter Jiangetal,2005 NM_001171 ABCC6 A1adenosinereceptor Pleiotropicphysiologicaleffects Nieetal,1998;Jhaverietal,2007 NM_000674 ADORA1 A2A Adenosinereceptor Morelloetal,2006 NM_000675 ADORA2A *ADAM19 Dendriticcellmarker Ehrnspergeretal,2005 NM_023038 ADAM19 Amiloride-sensitivesodiumchannel Sodiumchannel Bainesetal,2002;Haddad,2005 NM_001038 SCNN1A *alpha2B-adrenergicreceptor adrenergicreceptor Caylaetal,2004 NM_000682 ADRA2B BradykininB1-Receptor Pleiotropicphysiologicaleffects Nietal,1998 NM_000710 BDKRB1 *CD23 Cell-surfacemolecule Tinnelletal,1998 NM_002002 FCER2/CD23 CD69 LectinmainlyonactivatedTcells Lopez-Cabreraetal,1995 NM_001781 C69 DOR Deltaopiodreceptor Chenetal,2005,2006 NM_000911 OPRD1 EpidermalGrowthFactorReceptor ReceptorforEGF Nishietal,2003;Thornburg&Raab-Traub,2007 NM_005228 EGFR ErbB2 EGF-likereceptor Kitamuraetal,2005 NM_001005862 ERBB2 Gal1Receptor Galaninreceptor,neuroendocrinepeptide Lorimeretal,1997 NM_002256 KISS1 Lox-1 ReceptorforOxidizedlowdensitylipoprotein Nagaseetal,1998 NM_002543 OLR1 Ly49 ReceptoronNKcells Pascaletal,2007 NM_006611 KLRA1 Mdr1 Multipledrugresistancemediator(P-glycoprotein) Zhou&Kuo,1997;Wangetal,2007 NM_018849 ABCB4 Mu-opioidreceptor OpioidReceptor Krausetal,2003 EU360599 OPRM1 mGlu2 Metabotropicglutamatereceptor2 Chiechioetal,2006 NM_000839 GRM2 NeuropeptideY-Y1receptor Pleiotropicphysiologicaleffects Mussoetal,1997 NM_000909 NPY1R *NMDAreceptorsubunit2A(rat) NeuralreceptorforN-methyl-D-aspartate Richteretal,2002 NM_000833 GRIN2A *NMDAreceptorsubunitNR-1(GRIN1gene) SubunitofneuralreceptorforN-methyl-D-aspartate Begnietal,2003 NM_021569 GRIN1 Oxytocinreceptor Oxytocinreceptor Terizidouetal,2006 NM_000916 OXTR PAFreceptor1 Plateletactivatorreceptor Mutohetal,1994 NM_000952 PTAFR P-gp P-glycoprotein-Drugresistance Wangetal,2007 NM_000927 ABCB1 RAGE-receptorforadvancedglycationendproducts ReceptorforAdvancedGlycationEndproducts Li&Schmidt,1997 NM_001136 AGER Regulatorsofapoptosis Gene Function Reference Acc# HumanGeneName ASC Apoptosis-associatedspeck-likeproteincontainingaCARD Sunetal,2007 NM_013258 PYCARD Bax Pro-apoptoticBcl-2homologue Grimmetal,2004 NM_004324 BAX Bfl1/A1 Pro-survivalBcl-2homologue Grumontetal,1999;Zongetal,1999 NM_004049 BCL2A1 Bcl-xL Pro-survivalBcl-2homologue Chenetal,1999;Leeetal,1999 NM_138578 BCL2L1 Bcl-2 Pro-survivalfactor Catz&Johnson,2001 NM_000633 BCL2 Bim Pro-apoptoticBcl-2homolog Wangetal,2008 NM_138621 BCL2L11 B7-H1 Programmedcelldeathligand1 Leeetal,2005 NM_014143 CD274 BNIP3 Hypoxia-inducibledeathfactor Baetzetal,2005;Shawetal,2006 NM_004052 BNIP3 Caspase-11 Caspase Schauvliegeetal,2002 NM_001225 CASP4 Nr13 Pro-survivalBcl-2homologue Leeetal,1999 c-FLIP Pro-survivalfactor Kreuzetal,2001 NM_003879 CFLAR CD95(Fas) Pro-apoptoticreceptor Chanetal,1999;Zhouetal,2005;Singhetal,2006 NM_000043 FAS CIDEA Celldeath-inducingDFFA-likeeffectorA Petterssonetal,2008 NP_001270.1;NP_938031.1 CIDEA *Fas-associatedphosphatase-1 Proteinphosphatase Irieetal,2001 NM_006264 PTPN13 Fas-Ligand Inducerofapoptosis Matsuietal,1998;Singhetal,2006 NM_000639 FASLG IAPs InhibitorsofApoptosis Youetal,1997;Stehliketal,1998a,1998b IEX-1L Immediateearlygene Wuetal,1998 NM_052815 IER3 TRAF-1 TNF-receptorassociatedfactor Schwenzeretal,1999 NM_005658 TRAF1 TRAF-2 TNF-receptorassociatedfactor Wangetal,1998 NM_021138 TRAF2 *TRAF-2bindingprotein(Carp) TRAF2bindingprotein Changetal,2005 NM_052864 TIFA XIAP X-linkedinhibitorofapoptosis Turneretal,2007 NM_001167 XIAP Growthfactors,ligands,andtheirmodulators Gene Function Reference Acc# HumanGeneName ActivinA TGF-beta-likefactor Alexanderetal,2007 NM_002192 INHBA Angiopoietin Tie-2receptorligand Scottetal,2005 NM_001146 ANGPT1 BCAP B-cellAdaptorforPhosphoinositide3-kinase Guptaetal,2008 NM_152309 PI3KAP1 BDNF Brain-derivedneurotrophicfactor Sahaetal,2007 NM_001709 BDNF BLyS B-lymphocytestimulator Fuetal,2006 NM_006573 TNFSF13B BLNK B-celllinker Guptaetal,2008 NM_013314 BLNK BMP-2 BoneMorphogenicProtein-2 Fengetal,2003;Fukuietal,2006 NM_001200 BMP2 BMP-4 BoneMorphogenicProtein-4 Zhuetal,2007 NM_001202 BMP4 CGRP Calcitoningene-relatedpeptide Bowenetal,2005 NM_000728 CALCB FGF8 FibroblastGrowthFactor8 Armstrongetal,2006 NM_006119 FGF8 FLRG Follistatin-relatedgene Bartholinetal,2007 NM_005860 FSTL3 G-CSF GranulocyteColonyStimulatingFactor Nishizawa&Nagata,1990 NM_000759 CSF3 GM-CSF GranulocyteMacrophageColonyStimulatingFactor Schreck&Baeuerle,1990;Buntingetal,2007 NM_000758 CSF2 *HGF/SF Hepatocytegrowthfactor/scatterfactor Harrison&Farzaneh,2000 NM_000601 HGF EPO Erythropoietin Figueroaetal,2002 NM_000799 EPO *IGFBP-1 Insulin-likegrowthfactorbindingprotein-1 Langetal,1999 NM_001013029 IGFBP1 IGFBP-2 Insulin-likegrowthfactorbindingprotein-2 Cazalsetal,1999 NM_000597 IGFBP2 M-CSF(CSF-1) MacrophageColonyStimulatingFactor Brachetal,1991;Hohensinneretal,2007 NM_000757 CSF1 Midkine(neuritegrowthpromotingfactor-2) HeparinBindingGrowthFactor Youetal,2008 NM_001012334 MDK NGF NerveGrowthFactor Heeseetal,2006 NM_002506 NGFB NK-1R Neurokinin-1Receptor Simeonidisetal,2003;Ramkissoonetal,2007 NM_015727 TACR1 NK4 Hepatocytegrowthfactor Zhouetal,2003 NM_001012635 NK4 Nrg1 Neuregulin Frensingetal,2007 NM_004495 NRG1 OPN Osteopontin Samantetal,2007 NM_001040058 SPP1 PDGFBchain Platelet-derivedGrowthFactor Khachigianetal,1995;Auetal,2005 NM_002608 PDGFB PlGF PlacentaGrowthFactor Crameretal,2005 NM_002643 PIGF Proenkephalin Hormone Rattneretal,1991 NM_006211 PENK Prolactin Pituitaryhormone Friedrichsenetal,2005 NM_000948 PRL StemCellFactor MastCellGrowthFactor DaSilvaetal,2003;2004 NM_000899 KITLG *Thrombospondin-1(TSP-1) Matrixglycoproteint Yangetal,2003 NM_003246 THBS1 *Thrombospondin-2(THBS2) Matrixglycoproteint Adolphetal,1997 NM_003247 THBS2 VEGFC VascularEndothelialGrowthFactor Chilovetal,1997 NM_005429 VEGFC *WNT10B Secretedglycoprotein Katoh&Katoh,2007 NM_003394 WNT10B Earlyresponsegenes Gene Function Reference Acc# HumanGeneName *B94 Earlyresponsegene Zhouetal,2003 NM_006291 TNFAIP2 *Egr-1 Mitogen-inducedearlyresponsegene;zincfinger Zhouetal,2003 NM_001964 EGR1 p22/PRG1 RathomologueofIEX Schaferetal,1998 NM_052815 IER3 *p62 Non-proteasomalmulti-ubiquitinchainbindingprotein Vadlamudi&Shin,1998 NM_016221 DCTN4 *TIEG TGF-bearlyresponsegene;zincfingerprotein Zhouetal,2003 NM_001032282 KLF10 Transcriptionfactorsandtheirmodulators Gene Function Reference Acc# HumanGeneName A20 TNF-induciblezincfinger Krikosetal,1992 NM_006290 TNFAIP3 ABIN-3 NF-kBinhibitor Verstrepenetal,2007 NM_024873 TNIP3 Androgenreceptor Hormonereceptor Zhangetal,2004 NM_000044 AR Bcl-3 CoactivatorforNF-kBp50andp52 Brocke-Heidrichetal,2006 NM_005178 BCL3 BMI-1 Polycombchromatinmodifier Duttonetal,2006 NM_005180 BMI1 CDX1 Homeoboxprotein Wongetal,2005 NM_001804 CDX1 *c-fos(fishgene) Proto-oncogene Lietal,2004 NM_005252 FOS c-myb Proto-oncogene Tothetal,1995 NM_005375 MYB c-myc Proto-oncogene Duyaoetal,1990 NM_002467 MYC c-rel Proto-oncogene Hannink&Temin,1990;Capobianco&Gilmore,1991 NM_002908 REL C/EBPdelta Transcriptionfactor Liuetal,2007 NM_005195 CEBPD *DC-SCRIPT Dendriticcellzincfingerprotein Triantisetal,2006 NM_152625 ZNF366 Dmp1 Myb-liketranscriptionfactor Tanejaetal,2007 NM_001079911 DMP1 E2F3a Cellcycleregulator Chengetal,2003 NM_001949 E2F3 Elf3 Etsfamilytranscriptionfactor Houetal,2004 NM_004433 ELF3 *ELYS Embryoniclargemoleculederivedfromyolksac Okitaetal,2003 NM_015446 AHCTF1 *ETR101 TPA-inducible,Jun-liketranscriptionfactor Zhouetal,2003 NM_004907 IER2 Gata-3 T-celldifferentiationFactor Cornetal,2005 NM_001002295 GATA3 *Glucocorticoidreceptor Promoter1BoftheGR Schaff&Cidlowski,2002 NM_000176 NR3C1 HIF-1alpha Hypoxia-induciblefactor Bonelloetal,2007;Belaibaetal,2007;vanUdenetal,2008;Gorlach&Bonello,2008 NM_001530 HIF1A HOXA9 Homeoboxprotein Trivedietal,2007 NM_152739 HOXA9 IRF-1 Interferonregulatoryfactor-1 Haradaetal,1994;Robinsonetal,2006 NM_002198 IRF1 IRF-2 Interferonregulatoryfactor-2 Haradaetal,1994 NM_002199 IRF2 IRF-4 Interferonregulatoryfactor-4 Grumont&Gerondakis,2000;Saitoetal,2007 NM_002460 IRF4 IRF-7 Interferonregulatory    factor-7 Luetal,2002 NM_001572 IRF7 IkB-a InhibitorofRel/NF-kB Haskilletal,1991; NM_020529 NFKBIA Sunetal,1993 deMartinetal,1993 IkB-e InhibitorofRel/NF-kB Tianetal,2005 NM_004556 NFKBIE junB Proto-oncogene Brownetal,1995 NM_002229 JUNB jmjD3 Histonelysinedemethylase GNatoli,perscomm XM_043272 JMJD3 Lef1 TranscriptionfactorinWnt/b-cateninpathway Yunetal,2007 NM_016269 LEF1 LZIP Leukocytecellmobility Jangetal,2007 NM_006368 CREB3 Mail IkB-likeprotein Shiinaetal,2001;Itoetal,2004 NM_001005474 NFKBIZ nfkb2 NF-kBp100precursor Lombardietal,1995 NM_001077493 NFKB2 nfkb1 NF-kBp105precursor Tenetal,1992 NM_003998 NFKB1 NLRP2 NF-kBpathwayinhibitor Fontalbaetal,2007 NM_017852 NLRP2 NURR1 Nuclearorphanreceptor McEvoyetal,2002 NM_006186 NR4A2 Osterix Bonetranscriptionfactor Luetal,2006 AF477981 Osterix p53 TF,Tumorsuppressor Wu&Lozano,1994;Schummetal,2006 NM_000546 TP53 Progesteronereceptor Transcriptionfactor Condonetal,2005 NM_000926 PGR PU.1 Transcriptionfactor Bonadiesetal,2009 NM_001080547.1 SPI1 relb Transcriptionfactor Brenetal,2001 NM_006509 RELB Snail Transcriptionfactor Barberaetal,2004;Julienetal,2007 NM_005985 SNAI1 Sox9 Transcriptionfactor Murakamietal,2000 NM_000346 SOX9 Stat5a Transcriptionfactor Hinzetal,2002 NM_003152 STAT5A Tfec Transcriptionfactor Rehlietal,2005 NM_001018058 TFEC Twist Transcriptionrepressor Horikawaetal,2007;Phametal,2007 NM_000474 TWIST1 WT1 Zincfingertranscriptionfactor Dehbietal,1998;Chen&Williams,2000 NM_000378 WT1 YY1 Transcriptionfactor Wangetal,2007 NM_003403 YY1 Enzymes Gene Function Reference Acc# HumanGeneName *ABCTransporters ATP-bindingmembranetransporters Mutchetal,2003 NM_019625 ABCB9 *N-acetylglucosaminyltransferaseI(ratgene) N-acetylglucosaminyltransferase Fukudaetal,2003 NM_001097634 GCNT1 ADH Liveralcoholdehydrogenase Potteretal,2002 NM_000667 ADH1A AID Activation-inducedcytidinedeaminase Gourzietal,2007;Endoetal,2007 NM_020661 AICDA AMACR alpha-methylacyl-CoAracemase Chenetal,2007 NM_014324 AMACR ARF-relatedprotein-1 GTPase Muelleretal,2007 NM_003224 ARFRP1 Argininosuccinatesynthetase Argininesynthesis Fanetal,2005;Brasse-Lagneletal,2007 NM_000050 ASS1 Aromatase(promoterII) Estrogensynthesis Brasse-Lagneletal,2004 NM_000103 CYP19A1 ART2.1 Ecto-ADP-ribosyltransferase Hongetal,2007 NM_004314 ART1 alpha1ACT Anti-chymotrypsin Kissetal,2005 NM_001085 SERPINA3 BACE-1 betasiteAPPcleavingenzyme Sambamurtietal,2004;Rossneretal,2006:Bourneetal,2007;Bruggia-Prevotetal,2008 NM_012104 BACE1 Btk Bruton’sTyrosinekinase Yuetal,2008 NM_000061 BTK CathepsinB Lysosomalcysteineprotease Bienetal,2004 NM_001908 CTSB *CathepsinL Lysosomalcysteineprotease Sethetal,2003 NM_001912 CTSL1 cdk6 Cell-dependentkinase6 Iwanagaetal,2008 CDK6 *Ceramideglycosyltransferase Glycosphingolipid Ichikawaetal,1998 NM_020120 UGCGL1 Chitinase3-likeprotein Chitinase Reckliesetal,2005 NM_001276 CHI3L1 *cis-retinoid/androgendehydrogenasetype1(CRAD1) Shortchaindehydrogenase Chaietal,2001 NM_080436 Rdh1 *cis-retinoid/androgendehydrogenasetype2(CRAD2) Shortchaindehydrogenase Tomitaetal,2000 NM_017473 Rdh7 Collagenase1 Matrixmetalloproteinase Vincentietal,1998 NM_002421 MMP1 *Dihydrodioldehydrogenase Oxidoreductase,oxidationoftrans-hydodiols Ciaccioetal,1996 NM_00135 AKR1C1 *DYPD Dihydropyrimidinedehydrogenase Ukonetal,2005 NM_000110 DPYD DNASIL2 DNAse-likeendonuclease Shiokawaetal,2004 NM_001374 DNASE1L2 EL Endotheliallipase Kempeetal,2005 NM_006033 LIPG *ENO2 Enolase2gamma Carteretal,2002 NM_001975 ENO2 *GAD67 Glutamicaciddecarboxylase Szaboetal,1996 NM_000817 GAD1 GD3-synthase Sialyltransferase Zengetal,1998:Kangetal,2007 NM_003034 ST8SIA1 gp91phox SubunitofNADPHoxidase Anratheretal,2006 NM_007052 NOX1 GelatinaseB Matrixmetalloproteinase He,1996 NM_004994 MMP9 GSTP1-1 GlutathioneS-transferase Xiaetal,1996 NM_000852 GSTP1 Glutamate-cysteineligase GlutathioneS-transferasesynthesisenzyme Yangetal,2001;Nagashimaetal,2007 NM_001498 GCLC GCLC Glutamate-cysteineligasecatalyticsubunit Yangetal,2005 NM_001498 GCLC *Glutamate-cysteineligasemodifier GlutathioneS-transferasesynthesisenzyme Yangetal,2001 NM_002061 GCLM *gammaglutamylcysteinesynthetase Glutatamylcysteinesynthesis Chengetal,2005 NM_001498 GCLC *Glucosel-6-phosphatedehydrogenase Hexosemonophosphate Garcia-Nogalesetal,1999 NM_000402 G6PD Glucose-6-phosphatase Hexosephosphatase Xuetal,2007 NM_000151 G6PC GnRHII Gonadotropin-releasinghormoneII Hooetal,2007 NM_001501 GNRH2 GranzymeB NKcellcytotoxicity Huangetal,2006 NM_004131 GZMB *SolubleGuanylylcyclasealpha(1) ReceptorforNO Vazquez-Padronetal,2004 NM_000855 GUCY1A2 *Heparanase Cleavesheparin Caoetal,2005 NM_006665 HPSE HO-1 Hemeoxygenase Lavrovskyetal,1994;Rushworth&O’Connell,2004;Wuetal,2004;Linetal,2007 NM_002133 HMOX1 Hyaluronansynthase Synthesizeshyaluronicacid Ohkawaetal,1999;Kim,2006;Saavalainenetal,2007 NM_001523 HAS1 11bHSD2 11beta-hydroxysteroiddehydrogenasetype2 Kostadinovaetal,2005 NM_000196 HSD11B2 *17bHSD 17beta-hydroxysteroiddehydrogenase Villaretal,2007 NM_014234 HSD17B8 H+-K+ATPasealpha2 Roleinpotassiumhomeostasis Zhang&Kone,2002;Sahaetal2008 NM_000702 ATP1A2 Iodothyroninedeiodinase(type2) ConvertsT4toT3 Feketeetal,2003;Zeoldetal,2006 NM_000793 DIO2 *Indoleamine2,3-dioxygenase EnzymeforTrpsynthesis Ogasawaraetal,2009 NM_002164 IDO1 Lipocalin-typeprostaglandinDsynthase(L-PGDS) ProstaglandinD2synthaseinbrain Fujimorietal,2003 NM_000954 PTGDS Lysozyme Hydrolyzesbacterialcellwalls Phivan,1996 NM_000239 LYZ Mthfr Methylenetetrahydrofolatereductase Pickelletal,2005 NM_005957 MTHFR *MKP-1 MAPkinasephosphatase Zhouetal,2003 NM_004417 DUSP1 MMP-3,matrixmetalloproteinaase-3 Secretedcollagenaseinvolvedinmetastasis Borghaeietal,2004 NM_002422 MMP3 MMP-9,matrixmetalloproteinaase-9 Secretedcollagenaseinvolvedinmetastasis Bondetal,1998;Farinaetal,1999;Yanetal,2004 NM_004994 MMP9 MLCK (Long)Myosinlightchainkinase Grahametal,2006 NM_053025 MYLK iNOS Induciblenitricoxidesynthase Morrisetal,2003;Guoetal,2006;Hughesetal,2008 NM_000625 NOS2A n-NOS Neuronalnitricoxidesynthase Nakataetal,2006;Lietal,2007a,2007b NM_000620 NOS1 *PDE7A1 Phosphodiesterase7A1 Torras-Llort,&Azorin,2003 NM_002603 PDE7A PIM-1 Ser/Thrkinase Zhuetal,2002 NM_002648 PIM1 Plk3 Polo-like(Ser/Thr)kinase3 Lietal,2005 NM_004073 PLK3 PIK3CA Phosphatidylinositol3-kinasecatalyticsubunit Yangetal,2008 NM_006218 PIK3CA *PP5 Proteinphosphatase5 Matsudaetal,2003 NM_006247 PPP5C PKAalpha ProteinkinaseAisoform Kaltschmidtetal,2006 NM_002730 PRKACA PKCdelta ProteinkinaseDisoform Suhetal,2003 NM_006254 PRKCD PLCdelta1 PhospholipaseCisoform Kimetal,2003 NM_006225 PLCD1 *PTGIS,prostaglandinsynthase Prostaglandinsynthase Yokoyamaetal,1996 NM_000961 PTGIS *PGES,prostaglandinEsynthase Prostaglandinsynthase Zhouetal,2003 NM_004878 PTGES PTP1B Proteintyrosinephosphatase1B Zabolotnyetal,2008 NM_002827 PTPN1 PTHrP Parathryroidhormonerelatedprotein Nadellaetal,2007 NM_002820 PTHLH RACK1 ReceptorforActivatedCkinase Choietal,2003 NM_006098 GNB2L1 *REV3 DNApolymerasezeta Yuetal,2004 NM_002912 REV3L Slfn-2 Schlafen-2DNA/RNAhelicase Sohnetal,2007 NM_011408 Slfn2 Serpin2A Serineprotease Hampsonetal,2001 XM_372532 SERPINA2 SIAT1 Sialyltransferase Lo&Lau,1999 NM_173216 ST6GAL1 SNARK SNF1/AMPK-relatedkinase Legembreetal,2004 NM_030952 NUAK2 SSAT Spermidine/spermineN1-acetyltransferase Babbaretal,2006 NM_002970 SAT1 *SUV3 ATP-dependentRNAandDNAhelicase Minczuketal,2005 NM_003171 SUPV3L1 TERT Telomerasecatalyticsubunit Yinetal,2000:Hrdlickovaetal,2006 NM_198253 TERT Transglutaminase Formsisopeptidebonds Mirzaetal,1997 NM_000359 TGM1 TTG Tissuetransglutaminase Chenetal,2008 NM_004613 TGM2 TypeII-secretedphospholipaseA2 Proinflammatoryphospholipase Couturieretal,1999 NM_000437 PAFAH2 Uridinephosphorylase 5-fluorouracilandcapecitabinemetabolism Wanetal,2006 NM_003364 UPP1 *XanthineDehydrogenase Oxidativemetabolismofpurines Xuetal,1996 NM_000379 XDH Miscellaneous Gene Function Reference Acc# HumanGeneName *ABCG5(bovine) ATP-bindingcassettesteroltransporters Viturroetal,2006 NM_022436 ABCG5 ABCG8(bovine) ATP-bindingcassettesteroltransporters Viturroetal,2006 NM_022437 ABCG8 AbetaH-J-J Tripartitegene:aspartyl-beta-hydroxylase,junctin),junctate Feriottoetal,2005 NM_004318 ASPH alpha-1acidglycoprotein Serumprotein Mejdoubietal,1999 NM_000607 ORM1 alpha-fetoprotein Livercancermarker Cavinetal,2004 NM_001134 AFP AMH Anti-Mullerianhormone Lukas-Croisieretal,2003 NM_000479 AMH *beta-amyloid Alzheimer’sprecursor Song&Lahiri,1998 NM_000484 A4 APOBEC2 ApolipoporteinBmRNA-editingenzymecatalyticsubunit2 Matsumotoetal,2006 NM_006789 APOBEC2 ApolipoproteinCIII ApoproteinofHDL Gruberetal,1994 NM_000040 APOC3 ApolipoproteinD Plasmalipocalin DoCarmoetal,2007 NM_001647 APOD ApolipoproteinE Proteinassoc.withAlzheimers Lahiri,2004;Duetal,2005 NM_000041 APOE AQP4 Aquaporin4 Itoetal,2006 NM_001650 AQP4 *Biglycan Connectivetissueproteoglycan Ungefroren&Krull,1996 NM_001711 BGN BRCA2 BreastCancerSusceptibilityprotein-2 Wuetal,2000 NM_000059 BRCA2 Calsarcin-1 Musclecellcalcineurin-interactingprotein Wangetal,2007 NM_021245 MYOZ1 *Caveolin-1 Lipidraftprotein Deregowskietal,2002 NM_001753 CAV1 *Clone330 Possiblesecretedprotein Matsudaetal,2003 *Clone156 UnknownNF-kBinducer Matsudaetal,2003 *Clone68 UnknownNF-kBinducer Matsudaetal,2003 *p21-CIP1 Cyclin-dependentkinaseinhibitor Hinataetal,2003 NM_000389 CDKN1A *Claudin-2 Gapjunctionprotein Yamamotoetal,2004 NM_020384 CLDN2 a2(I)collagen TypeIcollagen Novitskiyetal,2004;Nieto,2007 NM_000089 COL1A2 *Connexin32 Gapjunctionprotein Yamamotoetal,2004 NM_000166 GJB1 CyclinD1 Cell-cycleregulation Guttridgeetal,1999;Hinzetal,1999;Toualbi-Abedetal,2008 NM_053056 CCND1 CyclinD2 Cell-cycleregulation Huangetal,2004;Iwanagaetal,2008 NM_001759 CCND2 *CyclinD3 Cell-cycleregulation Wangetal,1996 NM_001760 CCND3 DIF2 Monocytedifferentiationgene Witcheretal,2007 NM_003897 IER3 DMT1 Divalentmetaliontransporter Paradkaretal,2005 NM_000617 SLC11A2 Elafin Proteinaseinhibitor Bingleetal,2001 NM_002638 SKALP,PI3 Endothelin1 Vasoconstrictorpeptide/mitogen Quehenbergeretal,2000 NM_001955 EDN1 Ephrin-A1 Cell-cycleregulation Deregowskietal,2002 NM_005232 EPHA1 FactorVIII Hemostasis Figueiredo&Brownlee,1995 NM_000132 F8 FerritinHeavyChain Anti-oxidant Kwaketal,1995 NM_002032 FTH1 Gadd45beta DNArepair/cellcycle DeSmaeleetal,2001;Qiuetal,2004 NM_015675 GADD45B Galphai2 Gprotein Arinze&Kawai,2005 NM_002070 GNAI2 *GIF Cys-richmetalbindingprotein Hinataetal,2003 NM_005954 MT3 Galectin3 b-galactosidase-bindinglectin Hsuetal,1996 NR_003225 LGALS3 GBP-1 GTPaseguanylatebindingprotein Naschbergeretal,2004 NM_002053 GBP1 epsilon-Globin Globinprotein Houetal,2002,2004 NM_005330 HBE1 zeta-Globin Globinprotein Wang&Liebhaber,1999 NM_005332 HBZ *GS3686 Homologytomicrotubuleaggregatingprotein Carteretal,2002 NM_006820 IFI44L HairK5keratin Hairkeratinprotein Gilonetal,2007 NM_000424 KRT5 *HCCS1 Hepatocarcinomasuppressor1 Zhuetal,2006 NM_018289 VPS53 HMG14 Highmobilitygroup14 Walker&Enrietto,1996 NM_004965 HMGN1 IBABP Ilealbileacidbindingprotein Fangetal,2007 NM_001445 FABP6 IMP2 Insulin-likegrowthfactor-IImRNAbindingprotein Cleynenetal,2007 NM_000597 IGFBP2 K3Keratin Intermediatefilamentprotein Wuetal,1994 NM_057088 KRT3 K6bKeratin Intermediatefilamentprotein Komineetal,2000 NM_005555 KRT6B K15Keratin Intermediatefilamentprotein Radojaetal,2004 NM_002275 KRT15 *Lactoferrin Milkprotein Zhengetal,2005 NM_002343 LTF LamininB2Chain Basementmembraneprotein Richardsonetal,1995 NM_002292 LAMB2 Lipocalin-2 Iron-siderophore-bindingprotein Fujinoetal,2005 NM_005564 LCN2 Mts1 Multipletumorsuppressor Tulchinskyetal,1997 NM_002961 S100A4 Mir125b Micro-RNATNFa Tilietal,2007 Mir146a,b Micro-RNAforIRAKandTraf6 Taganovetal,2006 Mir155 Micro-RNAforFADD,IKKe,Ripk1 Tilietal,2007 MNE1 Monocyte/neutrophilelastaseinhibitor Zengetal,2000 NM_030666 SERPINB1 Mucin(MUC-2) Airwaydefenseglycoprotein Jonoetal,2002;Leeetal,2000 NM_002457 MUC2 Myelinbasicprotein Neuralsheath Paezetal,2006 NM_001025081 MBP MCT1 Monocarboxylatetransporterisoform1 Borthakuretal,2007 NM_003051 SLC16A1 Naf1 AssociateswithHIVNef Tianetal,2005 NM_006058 TNIP1 Neutrophilgelatinase-associatedlipocalin Anti-microbialproteininlung Cowlandetal,2003 NM_005564 LCN2 NLF1 IL-1betainduced Wartonetal,2004 NM_207322 FAM148A *p11 AnnexinIIligand Huangetal,2003 NM_002966 S100A10 PA28alpha Proteasomeactivator Ossendorpetal,2005 NM_006263 PSME1 PA28beta Proteasomeactivator Ossendorpetal,2005 NM_002818 PSME2 PAI-1 Plasminogenactivatorinhibitor Houetal,2004 NM_000602 SERPINE1,PAI-1 *Pax8 Pairedboxgene Okladnovaetal,1997 NM_003466 PAX8 *PCBD 6-pyruvoyl-tetrahydropterinsynthase Carteretal,2002 NM_000317 PTS Perforin Pore-formingeffectormolecule Zhouetal,2002 NM_005041 PRF1 PGC-1β mitochondrialregulatorPPAR-γcoactivator1β Bakkaret.al.2012 NM_001172698.1 PPARGC1B *PGK1 Phosphoglyceratekinase1 Carteretal,2002 NM_000291 PGK1 POMC Proopiomelanocortin Karalisetal,2004;Asabaetal,2007 NM_000939 POMC Pregnancy-specificglycoproteinrnCGM3 Placentalexpression Wangetal,2001 NM_019126 CGM3 Prodynorphin Neuropeptide Bakalkinetal,1994 NM_024411 PDYN Prostate-specificantigen Serumproteininprostatecancer Chen&Sawyers,2002 NM_001030047 KLK3 PTEN Tumorsuppressor Xiaetal,2007 NM_000314 PTEN RAG-1 Immunoglobulinrecombinasegenes Verkoczyetal,2005 NM_000448 RAG1 RAG-2 Immunoglobulinrecombinasegenes Verkoczyetal,2005 NM_000536 RAG2 RbAp48 Retinoblastoma-associatedprotein48 Pacificoetal,2007 NM_005610 RBBP4 *RICK Adaptor Matsudaetal,2003 NM_003821 RIPK2 SerpinE2 Serineproteaseinhibitor Suzukietal,2006 NM_006216 SERPINE2 S100A6(calcyclin) Calciumbindingprotein Jooetal,2003 NM_014624 S100A6 SH3BGRL SH3-bindingglutamicacid-richprotein Majidetal,2005 NM_003022 SH3BGRL SK2channels Small-conductanceCa2+-activatedchannels Kyeetal,2007 NM_021614 KCNN2 Skp2 S-phasekinase-associatedprotein2 Schneideretal,2006 NM_005983 SKP2 *Spergen-1 Sperm-specificmitochondrialprotein Matsuokaetal,2004 NM_174927 SPATA19 SWS1 Rainbowtroutopsin Dannetal,2004 NM_001708 OPN1SW Syncytin-1 Envglycoproteinofendogenoushumanretrovirus Mamelietal,2007 NM_014590 ERVWE1 Syndecan-4 Heparinsulfateproteoglycan Zhangetal,1999 NM_002999 SDC4 TAUT TaurineUptakeTransporter Mochizukietal,2005 NM_003043 SLC6A6 TASK-2 TandemPdomainpotassiumchannel Brazieretal,2005 NM_003740 KCNK5 *Tissuefactorpathwayinhibitor-2(TFPI-2) Serineproteaseinhibitor Kondurietal,2003a,2003b;Hubeetal,2003 NM_006528 TFPI2 *Transferrin(mosquito) Probableirontransportprotein Harizanovaetal,2005 NM_001063 TF TRIF TIR-containingadaptorproteininducinginterferonbeta Hardyetal,2004 NM_014261 TICAM1 TRPC1 Thrombinactivationofprotease-activatedreceptor-1 Pariaetal,2006 NM_003304 TRPC1 *UBE2M UbiquitinconjugatingenzymeE2M Carteretal,2002 NM_003969 UBE2M *UCP-2 Uncouplingprotein-2 Leeetal,1999 NM_003355 UCP2 UroplakinIb Surfacestructuralproteinonurothelialcells Vargaetal,2004 NM_006952 UPK1B 25-hydroxyvtaminD31alphahydroxylase EnzymeforlivervitaminD3production Ebertetal,2004 NM_000785 CYP27B1 Vimentin Intermediatefilamentprotein Lilienbaumetal,1990;Zhengetal,2005 NM_003380 VIM a1-antitrypsin Proteaseinhibitor Rayetal,1995 NM_000295 SERPINA1 Gro-1 Growthregulatedoncogene;chemokine Wood,1995 NM_001511 CXCL1 Viruses Gene Function Reference Adenovirus(E3region) Adenovirus Williamsetal,1990 AvianLeukosisVirus Causesavianleukosis Bowersetal,1996 BovineLeukemiaVirus Causesbovineleukemia Brooksetal,1998 CMV Cytomegalovirus Sambucettietal,1989 EBV(Wppromoter) Epstein-Barrvirus Suganoetal,1997 HBV(pregenomicpromoter) HepatitisBvirus Kwon&Rho,2002 HIV-1 Humanimmunodeficiencyvirus Nabel&Baltimore,1987;Griffinetal,1989 HSV(ICP90,ICPO) Herpessimplexvirus Rongetal,1992;LaFraziaetal,2006 JCVirus Polyomavirus Ranganathan&Khalili,1993 HPVtype16 HumanPapillomavirus Fontaineetal,2000 SIV Simianimmunodeficiencyvirus Bellasetal,1993 SV-40 Simianvirus40 Kannoetal,1989 For135additionalpotentialNF-kBtargetgenes,whicharepredictedbycomputer-basedmethodstohave compositeNF-kB/C/EBPregulatorysites,seeShelestetal.,2003. For9additionalpotentialNF-kBimmunefunctiontargetgenes,seeLiuetal.,2003. ForseveralhundredpredictedNF-kBtargetgenesinpancreaticcells,seeNaamaneetal,2007. Foradditionalc-Rel-specifictargetgenes,seeBuntingetal,2007. For23possibleadditionalNF-kBtargetsfrommicroarraysseeTakaseetal,2008 Seealsohttp://bioinfo.lifl.fr/NF-KB/fortargetgeneinformationandbindingsites. TheGilmoreLab GeneResources NF-kBTargetGenes cDNASequences MouseGeneKnockouts HumanGenes ProteinStructures PhysiologicalMediators OtherResources News BostonUniversitySearchDirectoryContactBUToday