杏仁核及紋狀體內之麩胺酸神經系統參與嗅球切除之大鼠所表現 ...

嗅球切除（olfactory bulbectomy）會誘使大鼠出現許多異常行為，例如：「攫殺小鼠行為」（mouse-killing behavior）、過激性（hyperirritability），而且該大鼠在新 ... 資料載入處理中... 跳到主要內容 臺灣博碩士論文加值系統 ::: 網站導覽| 首頁| 關於本站| 聯絡我們| 國圖首頁| 常見問題| 操作說明 English |FB專頁 |Mobile 免費會員 登入| 註冊 功能切換導覽列 (165.22.106.144)您好！臺灣時間：2022/05/2815:21 字體大小：       ::: 詳目顯示 recordfocus 第1筆/ 共1筆  /1頁 論文基本資料 摘要 外文摘要 目次 參考文獻 電子全文 紙本論文 QRCode 本論文永久網址: 複製永久網址Twitter研究生:何應瑞研究生(外文):Ying-Jui,Ho論文名稱:杏仁核及紋狀體內之麩胺酸神經系統參與嗅球切除之大鼠所表現之攫殺小鼠行為及其在新環境中之過動性論文名稱(外文):GlutamatergicSystemintheAmygdalaandStriatumIsInvolvedintheMouse-killingBehaviorandNoveltyExposure-inducedHyperactivityinOlfactoryBulbectomizedRats指導教授:蔡元奮、汪志雄指導教授(外文):Y.F.Tsai、C.S.Wang學位類別:博士校院名稱:國立臺灣大學系所名稱:生理學研究所學門:醫藥衛生學門學類:醫學學類論文種類:學術論文論文出版年:2002畢業學年度:90語文別:英文論文頁數:68中文關鍵詞:麩胺酸、嗅球切除、過動性、過激性、憂鬱症、小鼠攫殺行為、紋狀體、杏仁核外文關鍵詞:glutamate、olfactorybulbectomy、hyperactivity、hyperirritability、depression、mouse-killingbehavior、striatum、amygdala相關次數: 被引用:0點閱:442評分:下載:41書目收藏:2 嗅球切除（olfactorybulbectomy）會誘使大鼠出現許多異常行為，例如：「攫殺小鼠行為」（mouse-killingbehavior）、過激性（hyperirritability），而且該大鼠在新環境（novelenvironment）中會出現過動性（hyperactivity）。

嗅球廣泛投射麩胺酸神經纖維到杏仁核（amygdala），因此嗅球切除手術會導致麩胺酸神經系統之功能發生改變，這種改變可能參與嗅球切除之大鼠所出現的異常行為。

本論文第一部分之實驗以[3H]MK-801受體結合分析法探討大鼠經嗅球切除後，其各腦區內N-methyl-D-aspartate（NMDA）受體性質之變化。

實驗結果顯示，嗅球切除會導致杏仁核及大腦皮質內之NMDA受體密度降低，且紋狀體內NMDA受體對[3H]MK-801之親合力下降。

在第二部份之實驗，為釐清NMDA受體在攫殺小鼠行為中所扮演之角色，對嗅球切除之大鼠給予全身性投予NMDA受體之拮抗劑MK-801，或將MK-801以微透析探針局部灌流到內杏仁核（medialamygdala）。

實驗結果顯示，全身性或局部阻斷內杏仁核裡之NMDA受體，均會抑制嗅球切除之大鼠表現攫殺小鼠行為。

第三部份之實驗，以開放空間行為測定儀及微透析技術，探討嗅球切除之大鼠在新環境中所出現的過動性及紋狀體內麩胺酸釋放量之變化情形。

結果顯示新環境之壓力會導致嗅球切除之大鼠其紋狀體內之麩胺酸釋放量增加，而且合併出現過動性。

本論文第四部份之實驗係以ibotenicacid破壞基側杏仁核（basolateralamygdala），結果發現嗅球切除之大鼠在新環境中之過動性及麩胺酸神經系統過度活化之現象會受到抑制。

結論：杏仁核及紋狀體內之麩胺酸神經系統參與嗅球切除之大鼠所表現之攫殺小鼠行為及其在新環境中之過動性。

Olfactorybulbectomy(OBX)transectstheglutamatergicfibersprojectingfromolfactorybulbstotheamygdala;itcausesthechangesofglutamatergicactivityandconsequentlyresultsintheabnormalbehaviorsobservedinOBXrats,mouse-killingbehavioraswellashyperactivityinnovelenvironment.The[3H]MK-801bindingassaywasusedinthefirstexperimenttoevaluatethechangesofN-methyl-D-aspartate(NMDA)receptorbindingcharacteristicsfollowingOBX.TheresultsshowedthatOBXdecreasedthedensityofNMDAreceptorinthecortexandamygdalaandalsoreducedthe[3H]MK-801bindingactivitytotheNMDAreceptorsinthestriatum.Theresultsfromthesecondexperimentshowedthatthemouse-killingbehaviorinOBXratswasinhibitedbyMK-801administeredbyperitonealinjectionandlocoalperfusiontothemedialamygdala.Inthethirdexperiment,thenoveltyexposure-inducedhyperactivitywasaccompaniedbyanincreasingreleaseofstriatalglutamateinthestriatum.BoththehyperactivityandenhancedstriatalglutamatereleaseseeninOBXratsinnoveltyexposurewereblockedbytheibotenicacidlesionofthebasolateralamygdala,whichdemonstratedinthefourthexperiment.Takentogether,theseresultssuggestthattheglutamatergicpathwaysintheamygdalaandstriatumareinvolvedinthemouse-killingbehaviorandhyperactivityinOBXrats. 中文摘要3英文摘要4第一章文獻回顧5前言5第一節　與嗅球相關之神經聯繫5第二節　嗅球切除所誘發之行為變化6第三節　嗅球切除所誘發之神經系統功能變化8第四節　嗅球切除所誘發之內分泌系統功能變化10第五節　嗅球切除所誘發之免疫系統功能變化10第六節　精神藥物對嗅球切除所誘發行為的影響10第七節　與攫殺小鼠行為相關之神經系統11第八節　研究主題13第二章　嗅球切除造成大鼠腦內NMDA受體密度改變：[3H]MK-801受體結合分析法（實驗一）14中文摘要14英文摘要15背景說明16材料及方法17實驗結果20討論21第三章　MK-801對嗅球切除之大鼠其運動活性及攫殺小鼠行為之影響：NMDA受體所扮演之角色（實驗二）25中文摘要25英文摘要26背景說明27材料及方法27實驗結果30討論33第四章　基側杏仁核與麩胺酸神經系統參與嗅球切除之大鼠的過動行為37嗅球切除之大鼠暴露在新環境中誘發過動行為並增加紋狀體內麩胺酸之釋放量（實驗三）37中文摘要37英文摘要38背景說明39材料及方法39實驗結果41討論42破壞基側杏仁核抑制嗅球切除之大鼠在新環境中之過動性及紋狀體內麩胺酸神經系統之活性（實驗四）46中文摘要46英文摘要47背景說明48材料及方法49實驗結果50討論52第五章　總結及展望55參考文獻58 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訓育研究，38，25-33。

2. 吳怡欣、張景媛(民89)。

青少年與重要他人的情感關係和其自尊之相關研究暨訪談內容分析。

教育心理學報，32(1)，15-38。

3. 李鴻章(民89)。

出身背景教育程度與道德判斷之相關研究。

教育研究資訊，3(8)，14。

4. 李佩怡(民88)。

人際關係理論。

測驗與輔導，152，3153-3156。

5. 江文慈(民86)。

情緒智力(EQ)意涵的再解析。

諮商與輔導，136，3-8。

6. 林欽榮(民85)。

人際關係與溝通技巧。

人事管理，33，2-4。

7. 周煥臣(民75)。

人際關係的意義特性與功能。

教師之友，27(2)，35。

8. 周勳男(民68)。

情緒的表達與處理。

幼獅月刊，50(5)，55-61。

9. 柯永河(民86)。

教師的情緒管理。

學生輔導，51，40-51。

10. 許志錠(民81)。

人際關係與心理健康。

警學叢刊，22(4)，74-75。

11. 許淑穗(民90)。

做個快樂的教師-談健康的人際互動。

學生輔導，72，108-115。

12. 曹中瑋(民86)。

情緒的認識與掌控。

學生輔導通訊，51，26-39。

13. 陸正一(民87)。

人際溝通-情緒管理與控制。

品質管制月刊，34，22-28。

14. 陳小娥、蘇建文(民66)。

父母教養行為與少年生活適應。

教育心理學報，10，91-106。

15. 陳木金(民89)。

國民中小學生與家人相處情形之調查研究。

學生輔導，68，126-145。

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