CN106822505A - 一种治疗顽固性皮肤瘙痒的中药 - Google

生甘草清热解毒、调和药性，是为使药。

全方如此配伍，共凑养血活血、解毒除湿、祛风止痒之功。

[0025] 通过临床对照研究 ... CN106822505A-一种治疗顽固性皮肤瘙痒的中药 -GooglePatents 一种治疗顽固性皮肤瘙痒的中药 DownloadPDF Info Publicationnumber CN106822505A CN106822505A CN201710100142.9A CN201710100142A CN106822505A CN106822505A CN106822505A CN106822505A CN201710100142A CN201710100142A CN201710100142A CN106822505A CN106822505A CN106822505A Authority CN China Priorartkeywords medicine filtrate cooked 30min boiling Priorartdate 2017-02-23 Legalstatus(Thelegalstatusisanassumptionandisnotalegalconclusion.Googlehasnotperformedalegalanalysisandmakesnorepresentationastotheaccuracyofthestatuslisted.) Pending Applicationnumber CN201710100142.9A Otherlanguages English(en) Inventor 杨海燕 韩景辉 杨克勤 韩红艳 刘彩芳 CurrentAssignee(Thelistedassigneesmaybeinaccurate.Googlehasnotperformedalegalanalysisandmakesnorepresentationorwarrantyastotheaccuracyofthelist.) HenanUniversityofTraditionalChineseMedicineHUTCM OriginalAssignee HenanUniversityofTraditionalChineseMedicineHUTCM Prioritydate(Theprioritydateisanassumptionandisnotalegalconclusion.Googlehasnotperformedalegalanalysisandmakesnorepresentationastotheaccuracyofthedatelisted.) 2017-02-23 Filingdate 2017-02-23 Publicationdate 2017-06-13 2017-02-23 ApplicationfiledbyHenanUniversityofTraditionalChineseMedicineHUTCM filed Critical HenanUniversityofTraditionalChineseMedicineHUTCM 2017-02-23 PrioritytoCN201710100142.9A priority Critical patent/CN106822505A/zh 2017-06-13 PublicationofCN106822505A publication Critical patent/CN106822505A/zh Links Espacenet GlobalDossier Discuss 239000003814 drug Substances 0.000 title claims abstract description 58 208000003251 Pruritus Diseases 0.000 title claims abstract description 41 241000601164 Clematisorientalis Species 0.000 claims abstract description 13 240000001433 Acorusgramineus Species 0.000 claims abstract description 12 235000013073 Acorusgramineus Nutrition 0.000 claims abstract description 12 240000000774 Cunilaoriganoides Species 0.000 claims abstract description 12 235000018274 Cunilaoriganoides Nutrition 0.000 claims abstract description 12 235000014866 Dictamnusalbus Nutrition 0.000 claims abstract description 12 239000000463 material Substances 0.000 claims abstract description 12 241000218236 Cannabis Species 0.000 claims abstract description 11 235000001453 Glycyrrhizaechinata Nutrition 0.000 claims abstract description 11 235000006200 Glycyrrhizaglabra Nutrition 0.000 claims abstract description 11 235000017382 Glycyrrhizalepidota Nutrition 0.000 claims abstract description 11 229940010454 Licorice Drugs 0.000 claims abstract description 11 235000014063 licoriceroot Nutrition 0.000 claims abstract description 11 239000002994 rawmaterial Substances 0.000 claims abstract description 8 239000000706 filtrate Substances 0.000 claims description 24 XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances data:image/svg+xml;base64,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 data:image/svg+xml;base64,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 O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 18 238000009835 boiling Methods 0.000 claims description 15 241000202807 Glycyrrhiza Species 0.000 claims description 10 239000012467 finalproduct Substances 0.000 claims description 8 238000002386 leaching Methods 0.000 claims 1 210000004369 Blood Anatomy 0.000 abstract description 18 239000008280 blood Substances 0.000 abstract description 18 229940079593 drugs Drugs 0.000 abstract description 18 230000000694 effects Effects 0.000 abstract description 14 231100000614 Poison Toxicity 0.000 abstract description 13 230000017531 bloodcirculation Effects 0.000 abstract description 7 230000001737 promoting Effects 0.000 abstract description 7 239000003440 toxicsubstance Substances 0.000 abstract description 7 240000004670 Glycyrrhizaechinata Species 0.000 abstract 1 201000010099 disease Diseases 0.000 description 12 208000002193 Pain Diseases 0.000 description 7 210000003491 Skin Anatomy 0.000 description 7 210000000952 Spleen Anatomy 0.000 description 7 210000004185 Liver Anatomy 0.000 description 6 235000009508 confectionery Nutrition 0.000 description 6 238000001914 filtration Methods 0.000 description 6 208000006820 Arthralgia Diseases 0.000 description 5 210000002784 Stomach Anatomy 0.000 description 5 238000001035 drying Methods 0.000 description 5 239000002574 poison Substances 0.000 description 5 210000000936 Intestines Anatomy 0.000 description 4 201000004624 dermatitis Diseases 0.000 description 4 239000000796 flavoringagent Substances 0.000 description 4 235000019634 flavors Nutrition 0.000 description 4 206010010071 Coma Diseases 0.000 description 3 206010010774 Constipation Diseases 0.000 description 3 210000003414 Extremities Anatomy 0.000 description 3 206010062717 Increasedupperairwaysecretion Diseases 0.000 description 3 206010072736 Rheumaticdisease Diseases 0.000 description 3 238000003745 diagnosis Methods 0.000 description 3 201000004792 malaria Diseases 0.000 description 3 201000005404 rubella Diseases 0.000 description 3 206010000087 Abdominalpainupper Diseases 0.000 description 2 206010007247 Carbuncle Diseases 0.000 description 2 206010011224 Cough Diseases 0.000 description 2 206010011878 Deafness Diseases 0.000 description 2 208000002173 Dizziness Diseases 0.000 description 2 208000005679 Eczema Diseases 0.000 description 2 206010015037 Epilepsy Diseases 0.000 description 2 210000001624 Hip Anatomy 0.000 description 2 206010023126 Jaundice Diseases 0.000 description 2 210000003127 Knee Anatomy 0.000 description 2 210000004072 Lung Anatomy 0.000 description 2 206010030113 Oedema Diseases 0.000 description 2 206010062080 Pigmentationdisease Diseases 0.000 description 2 206010037844 Rash Diseases 0.000 description 2 206010039509 Scab Diseases 0.000 description 2 208000006641 SkinDisease Diseases 0.000 description 2 206010044684 Trismus Diseases 0.000 description 2 206010068760 Ulcers Diseases 0.000 description 2 210000003932 UrinaryBladder Anatomy 0.000 description 2 238000004458 analyticalmethod Methods 0.000 description 2 231100000895 deafness Toxicity 0.000 description 2 231100000406 dermatitis Toxicity 0.000 description 2 231100001003 eczema Toxicity 0.000 description 2 238000003379 eliminationreaction Methods 0.000 description 2 235000013305 food Nutrition 0.000 description 2 239000000203 mixture Substances 0.000 description 2 231100000862 numbness Toxicity 0.000 description 2 230000019612 pigmentation Effects 0.000 description 2 230000000607 poisoning Effects 0.000 description 2 231100000572 poisoning Toxicity 0.000 description 2 230000001225 therapeutic Effects 0.000 description 2 231100000397 ulcer Toxicity 0.000 description 2 210000001015 Abdomen Anatomy 0.000 description 1 206010000077 Abdominalmass Diseases 0.000 description 1 206010063409 Acarodermatitis Diseases 0.000 description 1 206010049865 Achromotrichiaacquired Diseases 0.000 description 1 241000251468 Actinopterygii Species 0.000 description 1 208000008784 Apnea Diseases 0.000 description 1 206010002974 Apnoea Diseases 0.000 description 1 210000001367 Arteries Anatomy 0.000 description 1 206010003549 Asthenia Diseases 0.000 description 1 210000000988 BoneandBones Anatomy 0.000 description 1 206010010904 Convulsion Diseases 0.000 description 1 241000721047 Danausplexippus Species 0.000 description 1 208000001848 Dysentery Diseases 0.000 description 1 208000005171 Dysmenorrhea Diseases 0.000 description 1 206010013935 Dysmenorrhoea Diseases 0.000 description 1 206010016256 Fatigue Diseases 0.000 description 1 210000003608 Feces Anatomy 0.000 description 1 206010018473 Glycosuria Diseases 0.000 description 1 206010018836 Haematochezia Diseases 0.000 description 1 208000002287 Hemorrhoids Diseases 0.000 description 1 206010020751 Hypersensitivity Diseases 0.000 description 1 206010022114 Injury Diseases 0.000 description 1 206010022437 Insomnia Diseases 0.000 description 1 210000003734 Kidney Anatomy 0.000 description 1 206010024229 Leprosy Diseases 0.000 description 1 206010027175 Memoryimpairment Diseases 0.000 description 1 206010027339 Menstruationirregular Diseases 0.000 description 1 210000003205 Muscles Anatomy 0.000 description 1 206010033557 Palpitations Diseases 0.000 description 1 206010033733 Papule Diseases 0.000 description 1 206010036790 Productivecough Diseases 0.000 description 1 208000008350 PruritusVulvae Diseases 0.000 description 1 206010037211 Psychomotorhyperactivity Diseases 0.000 description 1 241000208225 Rhus Species 0.000 description 1 208000005687 Scabies Diseases 0.000 description 1 241000447727 Scabies Species 0.000 description 1 210000004706 Scrotum Anatomy 0.000 description 1 206010039766 Scrubtyphus Diseases 0.000 description 1 208000005392 Spasm Diseases 0.000 description 1 210000003802 Sputum Anatomy 0.000 description 1 229960000351 Terfenadine Drugs 0.000 description 1 GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemicalcompound data:image/svg+xml;base64,<?xml version='1.0' encoding='iso-8859-1'?>
<svg version='1.1' baseProfile='full'
              xmlns='http://www.w3.org/2000/svg'
                      xmlns:rdkit='http://www.rdkit.org/xml'
                      xmlns:xlink='http://www.w3.org/1999/xlink'
                  xml:space='preserve'
width='300px' height='300px' viewBox='0 0 300 300'>
<!-- END OF HEADER -->
<rect style='opacity:1.0;fill:#FFFFFF;stroke:none' width='300.0' height='300.0' x='0.0' y='0.0'> </rect>
<path class='bond-0 atom-0 atom-1' d='M 83.9,155.1 L 65.0,159.8' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-0 atom-0 atom-1' d='M 80.1,152.0 L 66.9,155.3' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-34 atom-9 atom-0' d='M 89.2,136.3 L 83.9,155.1' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-1 atom-1 atom-2' d='M 65.0,159.8 L 51.4,145.8' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-2 atom-2 atom-3' d='M 51.4,145.8 L 32.5,150.6' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-6 atom-2 atom-7' d='M 51.4,145.8 L 56.8,127.1' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-6 atom-2 atom-7' d='M 56.0,144.1 L 59.7,131.0' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-3 atom-3 atom-4' d='M 32.5,150.6 L 27.8,131.7' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-4 atom-3 atom-5' d='M 32.5,150.6 L 37.3,169.5' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-5 atom-3 atom-6' d='M 32.5,150.6 L 13.6,155.3' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-7 atom-7 atom-8' d='M 56.8,127.1 L 75.6,122.3' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-8 atom-8 atom-9' d='M 75.6,122.3 L 89.2,136.3' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-8 atom-8 atom-9' d='M 74.9,127.2 L 84.4,136.9' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-9 atom-9 atom-10' d='M 89.2,136.3 L 108.1,131.6' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-10 atom-10 atom-11' d='M 108.1,131.6 L 109.6,126.3' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-10 atom-10 atom-11' d='M 109.6,126.3 L 111.1,121.0' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-11 atom-10 atom-12' d='M 108.1,131.6 L 121.7,145.6' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-12 atom-12 atom-13' d='M 121.7,145.6 L 140.6,140.8' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-13 atom-13 atom-14' d='M 140.6,140.8 L 154.1,154.8' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-14 atom-14 atom-15' d='M 154.1,154.8 L 160.3,153.2' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-14 atom-14 atom-15' d='M 160.3,153.2 L 166.4,151.7' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-15 atom-15 atom-16' d='M 178.5,155.8 L 182.6,159.9' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-15 atom-15 atom-16' d='M 182.6,159.9 L 186.6,164.0' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-35 atom-34 atom-15' d='M 178.3,131.3 L 176.6,137.4' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-35 atom-34 atom-15' d='M 176.6,137.4 L 174.9,143.5' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-16 atom-16 atom-17' d='M 186.6,164.0 L 205.5,159.3' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-17 atom-17 atom-18' d='M 205.5,159.3 L 210.8,140.5' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-18 atom-18 atom-19' d='M 210.8,140.5 L 229.7,135.8' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-32 atom-18 atom-33' d='M 210.8,140.5 L 197.2,126.6' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-19 atom-19 atom-20' d='M 229.7,135.8 L 228.3,130.4' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-19 atom-19 atom-20' d='M 228.3,130.4 L 227.0,125.1' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-20 atom-19 atom-21' d='M 229.7,135.8 L 248.6,131.0' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-26 atom-19 atom-27' d='M 229.7,135.8 L 234.4,154.7' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-21 atom-21 atom-22' d='M 248.6,131.0 L 262.1,145.0' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-21 atom-21 atom-22' d='M 253.4,130.4 L 262.9,140.2' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-36 atom-21 atom-26' d='M 248.6,131.0 L 253.9,112.3' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-22 atom-22 atom-23' d='M 262.1,145.0 L 281.0,140.3' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-23 atom-23 atom-24' d='M 281.0,140.3 L 286.4,121.5' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-23 atom-23 atom-24' d='M 278.1,136.4 L 281.8,123.3' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-24 atom-24 atom-25' d='M 286.4,121.5 L 272.8,107.5' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-25 atom-25 atom-26' d='M 272.8,107.5 L 253.9,112.3' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-25 atom-25 atom-26' d='M 270.9,112.0 L 257.7,115.4' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-27 atom-27 atom-28' d='M 234.4,154.7 L 220.5,168.2' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-27 atom-27 atom-28' d='M 235.1,159.5 L 225.3,169.0' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-37 atom-27 atom-32' d='M 234.4,154.7 L 253.2,160.0' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-28 atom-28 atom-29' d='M 220.5,168.2 L 225.2,187.1' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-29 atom-29 atom-30' d='M 225.2,187.1 L 243.9,192.5' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-29 atom-29 atom-30' d='M 229.1,184.2 L 242.2,187.9' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-30 atom-30 atom-31' d='M 243.9,192.5 L 257.9,178.9' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-31 atom-31 atom-32' d='M 257.9,178.9 L 253.2,160.0' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-31 atom-31 atom-32' d='M 253.4,177.0 L 250.1,163.8' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-33 atom-33 atom-34' d='M 197.2,126.6 L 178.3,131.3' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<text x='111.1' y='116.7' class='atom-11' style='font-size:7px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >O</text>
<text x='116.5' y='116.7' class='atom-11' style='font-size:7px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >H</text>
<text x='170.7' y='153.9' class='atom-15' style='font-size:7px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#4284F4' >N</text>
<text x='222.6' y='120.8' class='atom-20' style='font-size:7px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >O</text>
<text x='228.0' y='120.8' class='atom-20' style='font-size:7px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >H</text>
</svg>
 data:image/svg+xml;base64,<?xml version='1.0' encoding='iso-8859-1'?>
<svg version='1.1' baseProfile='full'
              xmlns='http://www.w3.org/2000/svg'
                      xmlns:rdkit='http://www.rdkit.org/xml'
                      xmlns:xlink='http://www.w3.org/1999/xlink'
                  xml:space='preserve'
width='85px' height='85px' viewBox='0 0 85 85'>
<!-- END OF HEADER -->
<rect style='opacity:1.0;fill:#FFFFFF;stroke:none' width='85.0' height='85.0' x='0.0' y='0.0'> </rect>
<path class='bond-0 atom-0 atom-1' d='M 23.3,43.5 L 17.9,44.8' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-0 atom-0 atom-1' d='M 22.2,42.6 L 18.4,43.6' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-34 atom-9 atom-0' d='M 24.8,38.2 L 23.3,43.5' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-1 atom-1 atom-2' d='M 17.9,44.8 L 14.1,40.9' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-2 atom-2 atom-3' d='M 14.1,40.9 L 8.7,42.2' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-6 atom-2 atom-7' d='M 14.1,40.9 L 15.6,35.6' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-6 atom-2 atom-7' d='M 15.4,40.4 L 16.4,36.7' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-3 atom-3 atom-4' d='M 8.7,42.2 L 7.4,36.9' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-4 atom-3 atom-5' d='M 8.7,42.2 L 10.1,47.6' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-5 atom-3 atom-6' d='M 8.7,42.2 L 3.4,43.6' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-7 atom-7 atom-8' d='M 15.6,35.6 L 20.9,34.2' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-8 atom-8 atom-9' d='M 20.9,34.2 L 24.8,38.2' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-8 atom-8 atom-9' d='M 20.7,35.6 L 23.4,38.4' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-9 atom-9 atom-10' d='M 24.8,38.2 L 30.1,36.8' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-10 atom-10 atom-11' d='M 30.1,36.8 L 30.4,35.8' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-10 atom-10 atom-11' d='M 30.4,35.8 L 30.7,34.7' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-11 atom-10 atom-12' d='M 30.1,36.8 L 34.0,40.8' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-12 atom-12 atom-13' d='M 34.0,40.8 L 39.3,39.5' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-13 atom-13 atom-14' d='M 39.3,39.5 L 43.2,43.4' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-14 atom-14 atom-15' d='M 43.2,43.4 L 44.9,43.0' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-14 atom-14 atom-15' d='M 44.9,43.0 L 46.6,42.6' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-15 atom-15 atom-16' d='M 50.5,44.1 L 51.4,45.1' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-15 atom-15 atom-16' d='M 51.4,45.1 L 52.4,46.0' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-35 atom-34 atom-15' d='M 50.0,36.8 L 49.5,38.5' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-35 atom-34 atom-15' d='M 49.5,38.5 L 49.1,40.1' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-16 atom-16 atom-17' d='M 52.4,46.0 L 57.7,44.7' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-17 atom-17 atom-18' d='M 57.7,44.7 L 59.2,39.4' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-18 atom-18 atom-19' d='M 59.2,39.4 L 64.6,38.0' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-32 atom-18 atom-33' d='M 59.2,39.4 L 55.4,35.4' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-19 atom-19 atom-20' d='M 64.6,38.0 L 64.3,36.9' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-19 atom-19 atom-20' d='M 64.3,36.9 L 64.0,35.8' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-20 atom-19 atom-21' d='M 64.6,38.0 L 69.9,36.7' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-26 atom-19 atom-27' d='M 64.6,38.0 L 65.9,43.4' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-21 atom-21 atom-22' d='M 69.9,36.7 L 73.8,40.7' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-21 atom-21 atom-22' d='M 71.3,36.5 L 74.0,39.3' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-36 atom-21 atom-26' d='M 69.9,36.7 L 71.4,31.4' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-22 atom-22 atom-23' d='M 73.8,40.7 L 79.1,39.3' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-23 atom-23 atom-24' d='M 79.1,39.3 L 80.6,34.0' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-23 atom-23 atom-24' d='M 78.3,38.2 L 79.3,34.5' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-24 atom-24 atom-25' d='M 80.6,34.0 L 76.8,30.0' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-25 atom-25 atom-26' d='M 76.8,30.0 L 71.4,31.4' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-25 atom-25 atom-26' d='M 76.3,31.3 L 72.5,32.3' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-27 atom-27 atom-28' d='M 65.9,43.4 L 62.0,47.2' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-27 atom-27 atom-28' d='M 66.1,44.8 L 63.3,47.5' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-37 atom-27 atom-32' d='M 65.9,43.4 L 71.2,44.9' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-28 atom-28 atom-29' d='M 62.0,47.2 L 63.3,52.6' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-29 atom-29 atom-30' d='M 63.3,52.6 L 68.6,54.1' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-29 atom-29 atom-30' d='M 64.4,51.8 L 68.1,52.8' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-30 atom-30 atom-31' d='M 68.6,54.1 L 72.6,50.3' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-31 atom-31 atom-32' d='M 72.6,50.3 L 71.2,44.9' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-31 atom-31 atom-32' d='M 71.3,49.7 L 70.4,46.0' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-33 atom-33 atom-34' d='M 55.4,35.4 L 50.0,36.8' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<text x='29.8' y='34.5' class='atom-11' style='font-size:6px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >O</text>
<text x='34.0' y='34.5' class='atom-11' style='font-size:6px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >H</text>
<text x='46.7' y='45.1' class='atom-15' style='font-size:6px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#4284F4' >N</text>
<text x='61.4' y='35.7' class='atom-20' style='font-size:6px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >O</text>
<text x='65.6' y='35.7' class='atom-20' style='font-size:6px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >H</text>
</svg>
 C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 description 1 208000009205 Tinnitus Diseases 0.000 description 1 206010044008 Tonsillitis Diseases 0.000 description 1 206010070863 Toxicitytovariousagents Diseases 0.000 description 1 231100000765 Toxin Toxicity 0.000 description 1 206010046736 Urticarias Diseases 0.000 description 1 210000003462 Veins Anatomy 0.000 description 1 241000700605 Viruses Species 0.000 description 1 206010056530 Vulvovaginalpruritus Diseases 0.000 description 1 238000009825 accumulation Methods 0.000 description 1 230000003213 activating Effects 0.000 description 1 230000000172 allergic Effects 0.000 description 1 230000000202 analgesic Effects 0.000 description 1 230000002052 anaphylactic Effects 0.000 description 1 230000001139 anti-pruritic Effects 0.000 description 1 239000003908 antipruriticagent Substances 0.000 description 1 210000000436 anus Anatomy 0.000 description 1 201000008937 atopicdermatitis Diseases 0.000 description 1 230000006399 behavior Effects 0.000 description 1 230000000903 blocking Effects 0.000 description 1 230000001684 chronic Effects 0.000 description 1 238000011109 contamination Methods 0.000 description 1 230000036461 convulsion Effects 0.000 description 1 230000018109 developmentalprocess Effects 0.000 description 1 238000005516 engineeringprocess Methods 0.000 description 1 230000029578 entryintohost Effects 0.000 description 1 238000002474 experimentalmethod Methods 0.000 description 1 239000004744 fabric Substances 0.000 description 1 201000005569 gout Diseases 0.000 description 1 230000002440 hepatic Effects 0.000 description 1 230000001939 inductiveeffect Effects 0.000 description 1 230000000749 insecticidal Effects 0.000 description 1 239000002917 insecticide Substances 0.000 description 1 238000007689 inspection Methods 0.000 description 1 210000002429 largeintestine Anatomy 0.000 description 1 201000009673 liverdisease Diseases 0.000 description 1 201000007227 lymphnodetuberculosis Diseases 0.000 description 1 238000000034 method Methods 0.000 description 1 230000000414 obstructive Effects 0.000 description 1 230000001314 paroxysmal Effects 0.000 description 1 230000008506 pathogenesis Effects 0.000 description 1 230000001717 pathogenic Effects 0.000 description 1 238000011084 recovery Methods 0.000 description 1 230000001105 regulatory Effects 0.000 description 1 230000002040 relaxanteffect Effects 0.000 description 1 210000002345 respiratorysystem Anatomy 0.000 description 1 238000006748 scratching Methods 0.000 description 1 230000002393 scratching Effects 0.000 description 1 230000000638 stimulation Effects 0.000 description 1 239000000126 substance Substances 0.000 description 1 201000004647 tineapedis Diseases 0.000 description 1 231100000886 tinnitus Toxicity 0.000 description 1 239000003053 toxin Substances 0.000 description 1 230000001960 triggered Effects 0.000 description 1 238000002562 urinalysis Methods 0.000 description 1 239000011800 voidmaterial Substances 0.000 description 1 Classifications A—HUMANNECESSITIES A61—MEDICALORVETERINARYSCIENCE;HYGIENE A61K—PREPARATIONSFORMEDICAL,DENTAL,ORTOILETPURPOSES A61K36/00—Medicinalpreparationsofundeterminedconstitutioncontainingmaterialfromalgae,lichens,fungiorplants,orderivativesthereof,e.g.traditionalherbalmedicines A61K36/18—Magnoliophyta(angiosperms) A61K36/185—Magnoliopsida(dicotyledons) A61K36/23—ApiaceaeorUmbelliferae(Carrotfamily),e.g.dill,chervil,corianderorcumin A61K36/232—Angelica A—HUMANNECESSITIES A61—MEDICALORVETERINARYSCIENCE;HYGIENE A61K—PREPARATIONSFORMEDICAL,DENTAL,ORTOILETPURPOSES A61K36/00—Medicinalpreparationsofundeterminedconstitutioncontainingmaterialfromalgae,lichens,fungiorplants,orderivativesthereof,e.g.traditionalherbalmedicines A61K36/18—Magnoliophyta(angiosperms) A61K36/185—Magnoliopsida(dicotyledons) A61K36/23—ApiaceaeorUmbelliferae(Carrotfamily),e.g.dill,chervil,corianderorcumin A61K36/238—Saposhnikovia A—HUMANNECESSITIES A61—MEDICALORVETERINARYSCIENCE;HYGIENE A61K—PREPARATIONSFORMEDICAL,DENTAL,ORTOILETPURPOSES A61K36/00—Medicinalpreparationsofundeterminedconstitutioncontainingmaterialfromalgae,lichens,fungiorplants,orderivativesthereof,e.g.traditionalherbalmedicines A61K36/18—Magnoliophyta(angiosperms) A61K36/185—Magnoliopsida(dicotyledons) A61K36/48—FabaceaeorLeguminosae(PeaorLegumefamily);Caesalpiniaceae;Mimosaceae;Papilionaceae A61K36/484—Glycyrrhiza(licorice) A—HUMANNECESSITIES A61—MEDICALORVETERINARYSCIENCE;HYGIENE A61K—PREPARATIONSFORMEDICAL,DENTAL,ORTOILETPURPOSES A61K36/00—Medicinalpreparationsofundeterminedconstitutioncontainingmaterialfromalgae,lichens,fungiorplants,orderivativesthereof,e.g.traditionalherbalmedicines A61K36/18—Magnoliophyta(angiosperms) A61K36/185—Magnoliopsida(dicotyledons) A61K36/48—FabaceaeorLeguminosae(PeaorLegumefamily);Caesalpiniaceae;Mimosaceae;Papilionaceae A61K36/489—Sophora,e.g.necklacepodormamani A—HUMANNECESSITIES A61—MEDICALORVETERINARYSCIENCE;HYGIENE A61K—PREPARATIONSFORMEDICAL,DENTAL,ORTOILETPURPOSES A61K36/00—Medicinalpreparationsofundeterminedconstitutioncontainingmaterialfromalgae,lichens,fungiorplants,orderivativesthereof,e.g.traditionalherbalmedicines A61K36/18—Magnoliophyta(angiosperms) A61K36/185—Magnoliopsida(dicotyledons) A61K36/60—Moraceae(Mulberryfamily),e.g.breadfruitorfig A—HUMANNECESSITIES A61—MEDICALORVETERINARYSCIENCE;HYGIENE A61K—PREPARATIONSFORMEDICAL,DENTAL,ORTOILETPURPOSES A61K36/00—Medicinalpreparationsofundeterminedconstitutioncontainingmaterialfromalgae,lichens,fungiorplants,orderivativesthereof,e.g.traditionalherbalmedicines A61K36/18—Magnoliophyta(angiosperms) A61K36/185—Magnoliopsida(dicotyledons) A61K36/70—Polygonaceae(Buckwheatfamily),e.g.spineflowerordock A61K36/704—Polygonum,e.g.knotweed A—HUMANNECESSITIES A61—MEDICALORVETERINARYSCIENCE;HYGIENE A61K—PREPARATIONSFORMEDICAL,DENTAL,ORTOILETPURPOSES A61K36/00—Medicinalpreparationsofundeterminedconstitutioncontainingmaterialfromalgae,lichens,fungiorplants,orderivativesthereof,e.g.traditionalherbalmedicines A61K36/18—Magnoliophyta(angiosperms) A61K36/185—Magnoliopsida(dicotyledons) A61K36/71—Ranunculaceae(Buttercupfamily),e.g.larkspur,hepatica,hydrastis,columbineorgoldenseal A61K36/716—Clematis(leatherflower) A—HUMANNECESSITIES A61—MEDICALORVETERINARYSCIENCE;HYGIENE A61K—PREPARATIONSFORMEDICAL,DENTAL,ORTOILETPURPOSES A61K36/00—Medicinalpreparationsofundeterminedconstitutioncontainingmaterialfromalgae,lichens,fungiorplants,orderivativesthereof,e.g.traditionalherbalmedicines A61K36/18—Magnoliophyta(angiosperms) A61K36/185—Magnoliopsida(dicotyledons) A61K36/75—Rutaceae(Ruefamily) A—HUMANNECESSITIES A61—MEDICALORVETERINARYSCIENCE;HYGIENE A61K—PREPARATIONSFORMEDICAL,DENTAL,ORTOILETPURPOSES A61K36/00—Medicinalpreparationsofundeterminedconstitutioncontainingmaterialfromalgae,lichens,fungiorplants,orderivativesthereof,e.g.traditionalherbalmedicines A61K36/18—Magnoliophyta(angiosperms) A61K36/88—Liliopsida(monocotyledons) A61K36/888—Araceae(Arumfamily),e.g.caladium,callalilyorskunkcabbage A—HUMANNECESSITIES A61—MEDICALORVETERINARYSCIENCE;HYGIENE A61K—PREPARATIONSFORMEDICAL,DENTAL,ORTOILETPURPOSES A61K2236/00—Isolationorextractionmethodsofmedicinalpreparationsofundeterminedconstitutioncontainingmaterialfromalgae,lichens,fungiorplants,orderivativesthereof,e.g.traditionalherbalmedicine A61K2236/30—Extractionofthematerial A61K2236/33—Extractionofthematerialinvolvingextractionwithhydrophilicsolvents,e.g.loweralcohols,estersorketones A61K2236/331—Extractionofthematerialinvolvingextractionwithhydrophilicsolvents,e.g.loweralcohols,estersorketonesusingwater,e.g.coldwater,infusion,tea,steamdistillation,decoction A—HUMANNECESSITIES A61—MEDICALORVETERINARYSCIENCE;HYGIENE A61K—PREPARATIONSFORMEDICAL,DENTAL,ORTOILETPURPOSES A61K2236/00—Isolationorextractionmethodsofmedicinalpreparationsofundeterminedconstitutioncontainingmaterialfromalgae,lichens,fungiorplants,orderivativesthereof,e.g.traditionalherbalmedicine A61K2236/30—Extractionofthematerial A61K2236/39—Complexextractionschemes,e.g.fractionationorrepeatedextractionsteps Abstract 本发明涉及治疗顽固性皮肤瘙痒的中药，可有效解决顽固性皮肤瘙痒的用药问题，其解决的技术方案是，该中药是由以下重量计的原料药物制成：当归15‑25g、威灵仙20‑40g、火麻仁20‑40g、石菖蒲15‑25g、苦参20‑40g、生首乌15‑25g、白鲜皮9‑15g、防风12‑18g和生甘草8‑12g，本发明原料丰富，组份科学，合理配伍，互相支持，诸药合用共奏养血活血，解毒除湿，祛风止痒之功效，有效用于治疗顽固性皮肤瘙痒症，疗效好，用药安全，是治疗顽固性皮肤瘙痒药物上的创新。

Description 一种治疗顽固性皮肤瘙痒的中药 技术领域 [0001]本发明涉及医药领域，特别是一种治疗顽固性皮肤瘙痒的中药。

背景技术 [0002]皮肤瘙痒是指无原发皮疹，但有瘙痒的一种皮肤病。

皮肤瘙痒症属于神经精神性皮肤病，是一种皮肤神经官能症疾患。

临床上将只有皮肤瘙痒而无原发性皮肤损害者称之为瘙痒症。

皮肤瘙痒分普通型和过敏型。

可全身发生，尤以面、背和四肢为多。

普通型皮肤瘙痒一般是皮肤太干燥造成的，皮肤瘙痒症的病因尚不明了，多认为与某些疾病有关，如糖尿病、肝病、肾病等；同时还与一些外界因素刺激有关，如寒冷、温热、化纤织物等。

[0003]皮肤瘙痒在中医领域，属中医“痒风”的范畴。

顽固性皮肤瘙痒容易反复复发，治愈困难，中华医药博大精深，治疗皮肤瘙痒的处方众多，然而多疗效不明确，治标不治本，因此，发明一种疗效确切的治疗顽固性皮肤瘙痒的中药势在必行。

发明内容 [0004]针对上述情况，为解决现有技术之缺陷，本发明之目的就是提供一种治疗顽固性皮肤瘙痒的中药，可有效解决顽固性皮肤瘙痒的用药问题。

[0005]本发明解决的技术方案是，该中药是由以下重量计的原料药物制成：当归15_25g、威灵仙20-40g、火麻仁20-40g、石菖蒲15-25g、苦参20-40g、生首乌15-25g、白鲜皮9-15g、防风12-18g和生甘草8-12g，其中，将上述原料药物混合在一起，加水浸没，浸泡30-60min，武火煎煮至沸腾后，改用文火煎煮20_30min，过滤，得滤液，滤渣再加水浸没，武火煎煮至沸腾后，改用文火煎煮20-30min，过滤，得滤液，合并两次滤液，即得。

[0006]本发明原料丰富，组份科学，合理配伍，互相支持，诸药合用共奏养血活血，解毒除湿，祛风止痒之功效，有效用于治疗顽固性皮肤瘙痒症，疗效好，用药安全，是治疗顽固性皮肤瘙痒药物上的创新。

具体实施方式 [0007]以下结合实施例对本发明的具体实施方式作进一步详细说明。

[0008]实施例1 [0009]本发明在具体实施时，可由以下重量计的原料药物制成：当归16g、威灵仙39g、火麻仁21g、石菖蒲14g、苦参21g、生首乌24g、白鲜皮10g、防风17g和生甘草9g，其中，将上述原料药物混合在一起，加水浸没，浸泡30-60min，武火煎煮至沸腾后，改用文火煎煮20-30min，过滤，得滤液，滤渣再加水浸没，武火煎煮至沸腾后，改用文火煎煮20_30min，过滤，得滤液，合并两次滤液，即得。

[0010]实施例2 [0011]本发明在具体实施时，还可由以下重量计的原料药物制成：当归20g、威灵仙30g、火麻仁30g、石菖蒲20g、苦参30g、生首乌20g、白鲜皮12g、防风15g和生甘草10g，其中，将上述原料药物混合在一起，加水浸没，浸泡30-60min，武火煎煮至沸腾后，改用文火煎煮20-30min，过滤，得滤液，滤渣再加水浸没，武火煎煮至沸腾后，改用文火煎煮20-30min，过滤，得滤液，合并两次滤液，即得。

[0012]实施例3 [0013]本发明在具体实施时，还可由以下重量计的原料药物制成：当归24g、威灵仙21g、火麻仁39g、石菖蒲16g、苦参39g、生首乌16g、白鲜皮14g、防风13g和生甘草llg，其中，将上述原料药物混合在一起，加水浸没，浸泡30_60min，武火煎煮至沸腾后，改用文火煎煮20-30min，过滤，得滤液，滤渣再加水浸没，武火煎煮至沸腾后，改用文火煎煮20-30min，过滤，得滤液，合并两次滤液，即得。

[0014]在本发明组分中： [0015]当归：性味归经:性温，味甘、辛。

归肝、心、脾经。

功能主治:补血活血，调经止痛，润肠通便。

用于血虚萎黄、眩晕心悸、月经不调、经闭痛经、虚寒腹痛、肠燥便秘、风湿痹痛、跌扑损伤、痈疽疮疡； [0016]威灵仙：辛咸，温，有毒，威灵仙有祛风除湿，通络止痛，消痰水，散癖积的功效。

威灵仙主治痛风顽痹、风湿痹痛，肢体麻木，腰膝冷痛，筋脉拘挛，屈伸不利，脚气，疟疾，症瘕积聚，破伤风，扁桃体炎，诸骨鲠咽； [0017]火麻仁:味甘，性平。

归脾、胃、大肠经。

具有润肠通便、滋养的功能。

生火麻仁长于润肠通便。

用于肠燥便秘； [0018]石菖蒲：辛、苦，温。

归心、胃经。

功能主治：化湿开胃，开窍豁痰，醒神益智。

用于脘痞不饥，噤口下痢，神昏癫痫，健忘耳聋。

理气，活血，散风，去湿。

治癫痫，痰厥，热病神昏，健忘，气闭耳聋，心胸烦闷，胃痛，腹痛，风寒湿痹，痈疽肿毒，跌打损伤； [0019]苦参:清热燥湿，祛风杀虫，用于湿热痢，肠风便血，黄疸，水肿，带下，阴痒，疥癣，麻风，皮肤瘙痒，湿毒疮疡； [0020]生首乌:性味:苦;甘;湿;性微温;归经:肝；肾经功能主治:养血滋阴；润肠通便;截疟;祛风;解毒。

主血虚头昏目眩；心悸;失眠;肝肾阴虚之腰膝酸软;须发早白；耳鸣;遗精；肠燥便秘;久疟体虚;风疹瘙痒;疮痈;瘰疬;痔疮； [0021]白鲜皮:性味:苦;咸;寒。

归经:脾经;肺经;小肠经；胃经;膀胱经。

功能:清热燥湿；祛风止痒;解毒。

主治:风热湿毒所致的风疹;湿疹;疥癣;黄疸;湿热痹； [0022]防风:味辛、甘，性微温。

归膀胱、肝、脾经。

功效:祛风解表，胜湿止痛，止痉定搐。

主治:外感表证，风疹瘙痒，风湿痹痛，破伤风； [0023]生甘草:性味:甘，平。

归经:归心、肺、脾、胃经。

功能主治:补脾益气，清热解毒，祛痰止咳，缓急止痛，调和诸药。

用于脾胃虚弱，倦怠乏力，心悸气短，咳嗽痰多，脘腹、四肢挛急疼痛，痈肿疮毒，缓解药物毒性、烈性。

[0024]本发明对于顽固性皮肤瘙痒立养血活血、解毒除湿、祛风止痒治疗大法，以经验方祛风止痒饮加减应用，在临床上取得显著疗效。

组方由当归、威灵仙、石菖蒲、生甘草、苦参、火麻仁、生首乌、白鲜皮、防风组成。

其中当归、威灵仙、火麻仁养血活血、润燥祛风以滋补肝血，且祛血虚之风燥，以绝风燥产生的根源，是为君药。

生首乌解毒，苦参清热燥湿、凉血杀虫，石菖蒲化湿理气、活血散风，白鲜皮清热燥湿、祛风解毒止痒，均为臣药，共凑清热燥湿、祛风解毒止痒之效。

一味防风既能祛外风以使表实不受邪，又能胜湿止痒，是为佐药。

生甘草清热解毒、调和药性，是为使药。

全方如此配伍，共凑养血活血、解毒除湿、祛风止痒之功。

[0025]通过临床对照研究，发现本发明临床疗效显著，为临床治疗顽固性皮肤瘙痒提供有效的、切实可行的从多病因多病机治疗的手段。

临床疗效显著，用药安全，并经临床实验得到了充分证明，有关临床实验资料如下： [0026]1、临床资料 [0027]1.1一般资料选自门诊患者120例，通过对120例顽固性皮肤瘙痒病人随机分组，随机分为治疗组与对照组各60例。

两组患者在性别、年龄、病程、病情等一般资料经统计学分析无显著性差异(P>〇.05)，具有可比性。

并顺利完成治疗、观察及数据统计分析工作。

[0028]2、诊断标准 [0029]1.全身性原发者，最初仅局限于一处，逐渐扩展至身体大部或全身。

局限性者，发生于身体的某一部位，以肛门、阴囊及女阴等处多见。

[0030]2.无原发性皮炎，由于搔抓可引起皮肤上出现抓痕、丘疹、血痂、色素沉着、湿疹样变及苔藓变样。

[0031]3.阵发性剧烈瘙痒，瘙痒发作常有定时的特点。

此外，尚有烧灼、虫爬及蚁行等感觉。

[0032]4.感情冲动、环境温度变化及衣服摩擦等刺激，都可引起瘙痒发作或加重。

[0033]3、纳入标准： [0034]1.皮肤瘙痒常为皮肤疾病的主要症状，有时可并有出疹、抓痕、血痂、苔藓变样及色素沉着。

[0035]2.根据病史、病情等进行诊断思考，如： [0036](1)皮肤瘙痒为突出表现，全身可无明显不适者，多为皮肤科疾病。

[0037](2)因食物、药物、虫毒或其他物质过敏、侵袭或中毒所致出疹，如漆疮、药毒、粉花疮、食鱼蟹中毒、野屎风、水毒、沙虱病、恶虫叮咬等，一般可通过病史询问而明确诊断，且多伴有瘙痒、风团、水肿等症。

[0038](3)年老体弱、气血亏虚者，其皮肤瘙痒，多为血虚风燥。

[0039]⑷由情绪波动而引发皮肤瘙痒，多为肝郁血虚。

[0040]3.皮肤专科检查，免疫生化实验检查，如过敏实验、致敏实验等，可以有助于明确诊断。

血常规、尿常规可作必备检查。

[0041]4、治疗方案 [0042]4.1对照组患者均予服用特非那定片，一次60mg，一日2次。

[0043]4.2治疗组服用本发明中药汤剂，早晚各一次，温服，每次200-300ml，两周为一个疗程，一个疗程后统计疗效； [0044]4.3疗效判定标准 [0045]痊愈:临床症状完全消失； [0046]显效:临床症状明显减轻； [0047]好转:临床症状减轻； [0048]无效:临床症状没有减轻。

[0049]5、统计学处理 [0050]5.1按上述治疗方案，口服本发明给出的中药组合物汤剂，治疗组60例，痊愈45例，显效12例，有效2例，无效1例，总有效率98.33%。

对照组60例，痊愈12例，显效14例，有效17例，无效17例，总有效率为71.67%(见表1)。

[0051]表1两组治疗结果比较 [0052] [0053]两组比较，*P〈0.05。

提示治疗组优于对照组。

[0054]6、结论 [0055]本发明组份科学，原料丰富，合理配伍，互相支持，诸药合用共奏养血活血，解毒除湿，祛风止痒之功效，适用于血虚湿盛，热毒内蕴，风邪浸淫导致的顽固性皮肤瘙痒，疗效好，用药安全，有效率高达98%以上，具有良好的推广和应用价值，临床意义巨大。

Claims(4) 1.一种治疗顽固性皮肤瘙痒的中药，其特征在于，该中药是由以下重量计的原料药物制成：当归15-25g、威灵仙20-40g、火麻仁20-40g、石菖蒲15-25g、苦参20-40g、生首乌15-25g、白鲜皮9-15g、防风12-18g和生甘草8-12g，其中，将上述原料药物混合在一起，加水浸没，浸泡30_60min，武火煎煮至沸腾后，改用文火煎煮20-30min，过滤，得滤液，滤渣再加水浸没，武火煎煮至沸腾后，改用文火煎煮20_30min，过滤，得滤液，合并两次滤液，即得。

2.根据权利要求1所述的治疗顽固性皮肤瘙痒的中药，其特征在于，由以下重量计的原料药物制成：当归16g、威灵仙39g、火麻仁21g、石菖蒲14g、苦参21g、生首乌24g、白鲜皮10g、防风17g和生甘草9g，其中，将上述原料药物混合在一起，加水浸没，浸泡30-60min，武火煎煮至沸腾后，改用文火煎煮20_30min，过滤，得滤液，滤渣再加水浸没，武火煎煮至沸腾后，改用文火煎煮20_30min，过滤，得滤液，合并两次滤液，即得。

3.根据权利要求1所述的治疗顽固性皮肤瘙痒的中药，其特征在于，由以下重量计的原料药物制成：当归20g、威灵仙30g、火麻仁30g、石菖蒲20g、苦参30g、生首乌20g、白鲜皮12g、防风15g和生甘草IOg，其中，将上述原料药物混合在一起，加水浸没，浸泡30-60min，武火煎煮至沸腾后，改用文火煎煮20_30min，过滤，得滤液，滤渣再加水浸没，武火煎煮至沸腾后，改用文火煎煮20_30min，过滤，得滤液，合并两次滤液，即得。

4.根据权利要求1所述的治疗顽固性皮肤瘙痒的中药，其特征在于，由以下重量计的原料药物制成：当归24g、威灵仙21g、火麻仁39g、石菖蒲16g、苦参39g、生首乌16g、白鲜皮14g、防风13g和生甘草IIg，其中，将上述原料药物混合在一起，加水浸没，浸泡30-60min，武火煎煮至沸腾后，改用文火煎煮20_30min，过滤，得滤液，滤渣再加水浸没，武火煎煮至沸腾后，改用文火煎煮20_30min，过滤，得滤液，合并两次滤液，即得。

CN201710100142.9A 2017-02-23 2017-02-23 一种治疗顽固性皮肤瘙痒的中药 CN106822505A (zh) PriorityApplications(1) ApplicationNumber PriorityDate FilingDate Title CN201710100142.9A CN106822505A (zh) 2017-02-23 2017-02-23 一种治疗顽固性皮肤瘙痒的中药 ApplicationsClaimingPriority(1) ApplicationNumber PriorityDate FilingDate Title CN201710100142.9A CN106822505A (zh) 2017-02-23 2017-02-23 一种治疗顽固性皮肤瘙痒的中药 Publications(1) PublicationNumber PublicationDate CN106822505A true CN106822505A (zh) 2017-06-13 Family ID=59133380 FamilyApplications(1) ApplicationNumber Title PriorityDate FilingDate CN201710100142.9A CN106822505A (zh) 2017-02-23 2017-02-23 一种治疗顽固性皮肤瘙痒的中药 CountryStatus(1) Country Link CN (1) CN106822505A (zh) Citations(2) *Citedbyexaminer,†Citedbythirdparty Publicationnumber Prioritydate Publicationdate Assignee Title CN101099774A (zh) * 2007-07-10 2008-01-09 尹克华 祛风止痒汤专治皮肤瘙痒症的中草药 CN101396491A (zh) * 2007-09-29 2009-04-01 孙承宽 一种5分钟消除遍身痒汁的制造方法 2017 2017-02-23 CN CN201710100142.9A patent/CN106822505A/zh active Pending PatentCitations(2) *Citedbyexaminer,†Citedbythirdparty Publicationnumber Prioritydate Publicationdate Assignee Title CN101099774A (zh) * 2007-07-10 2008-01-09 尹克华 祛风止痒汤专治皮肤瘙痒症的中草药 CN101396491A (zh) * 2007-09-29 2009-04-01 孙承宽 一种5分钟消除遍身痒汁的制造方法 Non-PatentCitations(1) *Citedbyexaminer,†Citedbythirdparty Title 林傲梵等主编:"《皮肤病防治305问》",30June2013,人民军医出版社 * SimilarDocuments Publication PublicationDate Title CN102772781B (zh) 2014-09-10 一种治疗慢性结肠炎的中药制剂及其制备方法 CN104256167A (zh) 2015-01-07 一种用于防治羊口炎的功能性饲料及其制备方法 CN102327443B (zh) 2013-03-20 一种治疗瘙痒型褥疮的中药洗剂的制备方法 CN105148210A (zh) 2015-12-16 一种治疗咳嗽的中药及其制备方法 CN102000164A (zh) 2011-04-06 一种治疗银屑病的中药组合物及其制备方法 CN107737330A (zh) 2018-02-27 一种治疗产后身痛的中药洗液 CN101249200B (zh) 2010-09-08 一种治疗表浅伤口的中药洗剂制备方法 CN105816760A (zh) 2016-08-03 一种活血化瘀、定痛止血、殓疮生肌、消炎止痛的膏药及其制备方法 CN102824590B (zh) 2013-11-27 一种治疗呼吸作痛型闭合性骨折的中药洗剂制备方法 CN104666799A (zh) 2015-06-03 软组织损伤活血化瘀药酒及制备方法 CN106822505A (zh) 2017-06-13 一种治疗顽固性皮肤瘙痒的中药 CN102793868B (zh) 2013-11-06 一种治疗喘促型闭合性骨折的中药洗剂制备方法 CN102380081B (zh) 2013-02-13 一种治疗麻木型褥疮的中药洗剂制备方法 CN104740543B (zh) 2017-12-22 一种治疗扁平疣的药物 CN103494948B (zh) 2015-10-14 一种治疗高血压高血糖高血脂的中草药 CN105770115A (zh) 2016-07-20 一种治疗湿疹的中药药膏 CN105770759A (zh) 2016-07-20 一种治疗阑尾炎的中药 CN105999131B (zh) 2019-06-04 一种治疗慢性前列腺炎的外用壮药组合物 CN102327497B (zh) 2012-11-21 一种治疗惊厥型褥疮的中药洗剂制备方法 CN105288239B (zh) 2019-04-16 一种活血化淤的中药组合物及其膏剂的制备方法 CN105943794A (zh) 2016-09-21 一种结合针灸治疗失眠症的中药及制备方法 CN109289028A (zh) 2019-02-01 一种治疗肠癌的中药组合物、其制备方法及应用 CN105168275A (zh) 2015-12-23 一种治疗咳嗽的药物及其制备方法 CN102631573A (zh) 2012-08-15 一种治疗溲赤型红丝疔的中药洗剂制备方法 CN105687847A (zh) 2016-06-22 一种治疗热淋型淋证病的中药 LegalEvents Date Code Title Description 2017-06-13 PB01 Publication 2017-06-13 PB01 Publication 2017-07-07 SE01 Entryintoforceofrequestforsubstantiveexamination 2017-07-07 SE01 Entryintoforceofrequestforsubstantiveexamination 2021-04-30 RJ01 Rejectionofinventionpatentapplicationafterpublication 2021-04-30 RJ01 Rejectionofinventionpatentapplicationafterpublication Applicationpublicationdate: 20170613