沈延盛-醫學院院長 - 外科學科

沈延盛-醫學院院長 · 12. · Yung-Yeh Su, Nai-Jung Chiang, Hui-Jen Tsai, Chia-Jui Yen, Yan ·, Li · ‐ · Tzong Chen. · Efficacy of Nanoliposomal Irinotecan and Impact on ... 跳到主要內容區 沈延盛-醫學院院長 姓名:沈延盛醫師 主要學歷 畢業學校 科系所 學位 成功大學 臨床醫學研究所 博士 成功大學 醫學院學士後醫學系 醫學士 現職 服務機關 服務部門 職稱 國立成功大學醫學院 院長 國立成功大學醫學院 外科部 合聘教授 國立成功大學 臨床醫學研究所 特聘教授 科技部推動規劃補助計畫 上消化道癌臨床試驗合作聯盟 召集人 衛福部第三期卓越癌症平台計劃 胰臟癌研究團隊 召集人 國立成功大學醫學院附設醫院 外科部 主治醫師 經歷 服務機關 服務部門 職稱 國立成功大學 外科部 助理教授        國立成功大學 外科部 副教授 國立成功大學 臨床醫學研究所 副教授 國立成功大學 臨床醫學研究所 教授 國立成功大學醫學院附設醫院 上消化道癌醫療團隊 召集人 國立成功大學醫學院附設醫院 外傷科 主任 國立成功大學醫學院附設醫院 臨床醫學研究中心 主任 國立成功大學 臨床醫學研究所 所長 專長 臨床 肝膽胰外及胃腸腫瘤外科學,外科營養學, 外科感染學,胃腸生理學 研究 肝胰再生醫學,腫瘤學(腫瘤微環境的研究:癌幹細胞,腫瘤相關免疫細胞及腫瘤相關纖維細胞的交互作用),胃腸基質瘤轉移的機轉,靜脈及腸道營養在術後的應用 學術成大 學術論文 SelectedPublications(morethan150papers,selectedsince2015) Book: Ying-JuiChao,Yan-ShenShan*.LaparoscopicPancreaticoduodenectomy.InInnovationanddiagnosisforpancreaticcancer.HirokiYamaue(ed.),Chap10;page:129-145.SpringerSingapore2017 Papers 1.      WeihsunLu,Hong-MingTsai,Ying-JuiChao,Ting-KaiLiao,Yan-ShenShan*.Pancreaticregenerationandchangesinendocrinefunctionafterpancreatectomy.2019(submitted) 2.      Chien-HsienYeh,Fong-ChinSu,Yan-ShenShan,MaratDosaev,YurySelyutskiy,IrinaGoryacheva,MingJu.ApplicationofPiezoelectricActuatortoSimplifiedHapticFeedbackSystem.Sensors&Actuators:A.Physical.2020Mar1,vol303:111820(Accepted). 3.      Chang-FangChiu,Jing-RuWeng,Shou-LunLee,Chia-YungWu,Po-ChenChu,Yan-ShenShan,Horng-RenYang,Li-YuanBai*.OSU-A9induced-reactiveoxygenspeciescausecytotoxicityinduodenalandgastriccancercellsbydecreasingphosphorylatednuclearpyruvatekinaseM2proteinlevels.BiochemicalPharmacology2020 Jan16:113811.doi:10.1016/j.bcp.2020.113811 4.      Ying-JuiChao,Yu-LunChen,Ya-ChinHou,Hao-ChenWang,Pei-JungLu,Yan-ShenShan*.PoorclinicopathologicroleofTBC1D23innon-smallcelllunganditspotentialpathwaybybioinformaticsanalysis.OncoTargetandTherapy2019(Revised). 5.      Ming-HuangChen,Wen-ChiChou,Chin-FuHsiao,Shih-ShengJiang,Hui-JenTsai,Yi-ChangLiu,ChiunHsu,Yan-ShenShan,Yi-PingHung,Chia-HsunHsich,Chao-HuaChiu,Ta-ChihLiu,Shih-FengCho,Tsang-WuLiu,YeeChao.AnOpen-Label,Single-Arm,Two-Stage,Multicenter,PhaseIIStudytoEvaluatetheEfficacyofTLC388andGenomicanalysisforPoorlyDifferentiatedNeuroendocrineCarcinomas.Oncologist.2019Dec18.doi:10.1634/theoncologist.2019-0490. 6.      HsuCC,LiaoWY,ChanTS,ChenWY,LeeCT,ShanYS,HuangPJ,HouYC,LiCR,TsaiKK.ThedifferentialdistributionsofASPMisoformsandtheirrolesinWntsignaling,cellcycleprogression,andpancreaticcancerprognosis.JPathol.2019Aug29.doi:10.1002/path.5341. 7.      DivinahManohran,Li-ChanChang,Liu-ChunWang,Yan-ShenShan,Forn-ChiaLin,Lai-ChinWu,Hwo-ShuennSheu,Wen-PenSu,Chen-ShengYeh.Low-doseX-ray-excitedintegratedscintillatingnanoparticlesenhancedX-raytherapyincontrolledchemotherapywithhighlytargetingpancreatictumorshowingsynergisticeffect. JACS2020(revised) 8.      Yan-ShenShanetal.Validationofgenome-wideassociationstudy-identifiedsinglenucleotidepolymorphismsinacase-controlstudyofpancreaticcancerfromTaiwan.2019(submitted). 9.      PriyaGopinathan,Nai-JungChiang,AnandarajuBandaru,AnirbanSinha,Wen-YenHuang,Shang-ChengHung#,Yan-ShenShan#,Gwo-BinLee#.Exploringcirculatingtumorcellsincholangiocarcinomausinganovelglycosaminoglycanprobeonamicrofluidicplatform.2019(submitted) 10.  Ya-ChinHou,Ching-ChengHsu,Hui-LingTung,Min-HuaHsieh,Hao-ChenWang,Yi-ChingWang,andYan-ShenShan*.Rab37mediatesexosomalosteopontinsecretiontopromotepancreaticcancermetastasisandstemness.2020(submitted) 11.  Chia-LungYang,Ying-JuiChao,Hao-ChenWang,Ya-ChinHou,Gong-ShenChen,Chia-ChingChang, Yan-ShenShan.*LocalablationofgastriccancerbyreconstitutedapolipoproteinBlipoparticlescarryingdemethylationdrugs.NBM2020(revised) 12.  Yung-YehSu,Nai-JungChiang,Hui-JenTsai,Chia-JuiYen,Yan‐ShenShan*,Li‐TzongChen. EfficacyofNanoliposomalIrinotecanandImpactonSurvivalofAdvancedPancreaticDuctalAdenocarcinoma:ASingleInstitutionalExperience.SciRep2019(Revised) 13.  Hui-JuCh’ang,Yen-FengChiu,Jen-HsiChen,Chung-PinLi,Ching-LiangHo,Yi-MingShyr,Wen-ChiChou,Chun-NanYeh,Ruey-KuenHsieh,Yu-LinLin,Yu-WenTien,Tsann-LongHwang,Yan-ShenShan*,Li-TzongChen,onbehalfoftheTaiwanCooperativeOncologyGrouppancreaticcancerstudygroup. RandomizedPhaseIIIStudyComparingAdjuvantGemcitabineversusGemcitabineplusChemoradiationinCurativelyResectedPancreaticCancer.2019(submitted) 14.  Yung-JueBang,Chung-PinLi,Kyung-HunLee,Chang-FangChiu,JoonOhPark,Yan-ShenShan,JunSukKim,Jen-ShiChen,Hyun-JeongShim,Kun-MingRau,HyeJinChoi,Do‑YounOh,BruceBelanger,Li-TzongChen.LiposomalirinotecaninmetastaticpancreaticadenocarcinomainAsianpatients:subgroupanalysisoftheNAPOLI-1study.CancerScience2019Dec1.doi:10.1111/cas.14264. 15.  MargaretA.Tempero,HannoRiess,UwePelzer,EileenO'Reilly,JordanWinter,Do-YounOh,Chung-PinLi,GiampaoloTortora,Heung-MoonChang,CharlieLopez,TaniosBekaii-Saab,AndrewKo,ArmandoSantoroJoonOhPark,MarcusNoel,GiovanniLucaFrassineti,Yan-ShenShan,MingyuLi,StefanoFerrara,BrianLuAndrewDean,MicheleReni,onbehalfoftheAPACTinvestigators.PhaseIIIMulticenter,International,Open-Label,RandomizedTrialofAdjuvantnab-Paclitaxel(nab-P)plusGemcitabine(Gem)vsGemAloneforSurgicallyResectedPancreaticAdenocarcinoma2019(submitted) 16.  Nai-JungChiang,KelvinK.Tsai,Chin-FuHsiao,Shih-HungYang,Hui-HuaHsiao,Wen-ChiShen,ChiunHsu, Yu-LinLin,Jen‐ShiChen,Yan-ShenShan*,Li-TzongChen.AMulticenter,PhaseI/IITrialofBiweeklyS-1,Leucovorin,OxaliplatinandGemcitabineinMetastaticPancreaticAdenocarcinoma-TCOGT1211Study.EurJCancer.2019Nov22;124:123-130. 17.  Hao-ChenWang,Yung-LunLin,Ching-ChengHsu,Ying-JuiChao,Ya-ChinHou,Tai-JanChiu,Po-HsienHuang,Ming-JerTang,Li-TzongChen,Yan-ShenShan*.PancreaticstellatecellsactivatedbymutantKRAS-mediatedPAI-1upregulationfosterpancreaticcancerprogressionviaIL-8.Theranostics2019Sep23;9(24):7168-7183. 18.  Yuan-ShuoHsueh,HuiHuaChang,Yan-ShenShan,H.SunnySun,JonathanAlfredFletcher,Chien-FengLi,Li-TzongChen.NuclearKITinducesaNFKBIB-RELA-KITautoregulatoryloopinimatinib-resistantgastrointestinalstromaltumors.Oncogene2019Sep;38(38):6550-6565. 19.  WengCC,HsiehMJ,WuCC,LinYC,ShanYS,HungWC,ChenLT,ChengKH.LossofthetranscriptionalrepressorTGIF1resultsinenhancedKras-drivendevelopmentofpancreaticcancer.MolCancer.2019May20;18(1):96. 20.  Ya-ChinHou,Ying-JuiChao,Min-HuaHsieh,Hui-LingTung,Hao-ChenWang,andYan-ShenShan*.LowCD8+TcellinfiltrationandhighPD-L1expressionareassociatedwithCD44+/CD133+cancerstemcellsandpredictanunfavorableprognosisinpancreaticcancer.Cancers(Basel).2019Apr15;11(4) 21.  Ming-ChuanHsu;Ya-LiTsai;Chia-HsienLin;Mei-RenPan;Yan-ShenShan;Tsung-YenCheng;SkyeHung-ChunCheng;Li-TzongChen;Wen-ChunHung.Proteinargininemethyltransferase3-inducedmetabolicreprogrammingisavulnerabletargetofpancreaticcancer.JournalofHematology&Oncology2019Jul19;12(1):79. 22.  JeffreyS.Chang,Sung-HsinKuo;Pei-YiChu;Yan-ShenShan;Chia-RungTsai;Hui-JenTsai;Li-TzongChen.TheepidemiologyofgastriccancersintheeraofHelicobacterpylorieradication:anation-widecancerregistry-basedstudyinTaiwan.CancerEpidemiolBiomarkersPrev.2019Oct;28(10):1694-1703. 23.  WangCJ,LinSY,TsaiSH,ShanYS.Implicationsoflong-termlow-fidelityinsitusimulationinacutecareandassociationwithareductioninunexpectedcardiacarrests:Aretrospectiveresearchstudy.PLoSOne.2019Mar12;14(3):e0213789. 24.  Tsui-MaiKao,Yi-ShengLiu,Yan-ShenShan,Hu-JuCh'ang,Li-TzongChen.Cureofunresectablelocallyadvancedpancreaticcanceraftermultidisciplinarytherapy.JCancerResearch&Practice.2018(0nline) 25.  LeeKT,ChangCL,LiCY,SongH,ShanYS,LaiMD.TheoncogenicroleofMST3inhumangastriccancer.AmJCancerRes.2018Oct1;8(10):2130-2139. 26.  ChihJungWang,EdgarD.Sy,YingJuiChao,YanShenShan.ASimplemethodofIntracorporeal“W-shaped”LiverRetractionTechniqueforMinimallyInvasiveGastricCancerSurgery.SurgLapEndoscPercutTech2019Jun;29(3):e24-e28. 27.SyED,ShanYS,LinCH.Vitellinefistulaassociatedwithomphalocele:Diagnosticdilemma?IntJSurgCaseRep.2018;47:45-47. 28.Tzu-LeiKuo,Kuang-HungCheng,Yan-ShenShan,Li-TzongChen,Wen-ChunHung.β-catenin-activatedautocrinePDGF/Srcsignalingisatherapeutictargetinpancreaticcancer.Theranostics2019Jan1;9(2):324-336. 29.  Hsin-HsienYu,YutakaYonemura,Mao-ChihHsieh,Chang-YunLu,Szu-YuanWu,Yan-ShenShan* Experienceofapplyingcytoreductivesurgeryandhyperthermicintraperitonealchemotherapyforovarianteratomawithmalignanttransformationandperitonealdissemination.TherapeuticsandClinicalRiskManagement.2019;15:129-136. 30.Hsin-HsienYu,Mao-ChihHsieh,Szu-YuanWu,EdgarD.Sy,Yan-ShenShan*.EffectsofDuodenal–JejunalBypassSurgeryinAmelioratingNonalcoholicSteatohepatitisinDiet-InducedObeseRats. Diabetes,MetabolicSyndromeandObesity:TargetsandTherapy2019;12:149–159. 31.  Ming-ChuanHsu,Mei-RenPan,Pei-YiChu,Ya-LiTsai,Chia-HuaTsai,Yan-ShenShan,Li-TzongChen,Wen-ChunHung*Proteinargininemethyltransferase3enhanceschemoresistanceinpancreaticcancerbymethylatinghnRNPA1toincreaseABCG2expression.Cancers2018Dec20;11(1).pii:E8.doi:10.3390/cancers11010008. 32.Ya-ChinHou,Chih-JungWang,Ying-JuiChao,Hao-YunChen,Hao-ChenWang,Hui-LingTung,Jung-TingLin,Yan-ShenShan*.ElevatedserumInterleukin-8levelcorrelateswithcancer-relatedcachexiaandsarcopenia:anindicatorforpancreaticcanceroutcomes.JCM2018Dec1;7(12).pii:E502.doi:10.3390/jcm7120502. 33.  ChenLT,SivekeJT,Wang-GillamA,LiCP,BodokyG,DeanAP,ShanYS,JamesonGS,MacarullaT,LeeKH,CunninghamD,BlancJF,ChiuCF,SchwartsmannG,BraitehFS,MamloukK,BelangerB,deJongFA,HubnerRA.Survivalwithnal-IRI(liposomalirinotecan)plus5-fluorouracilandleucovorinversus5-fluorouracilandleucovorininper-protocolandnon-per-protocolpopulationsofNAPOLI-1:Expandedanalysisofaglobalphase3trial.EurJCancer.2018Nov7;105:71-78. 34.  YangTH,ChenJL,LinYJ,ChaoYJ,ShanYS,HsuHP,SuZM,ChouCC,YenYT.Laparoscopicsurgeryforlargeleftlaterallivertumors:safetyandoncologicoutcomes.SurgEndosc.2018Oct;32(10):4314-4320. 35.  Hsin-HsienYu,Chia-LunChang,KevinSheng-PoYuan,AlexanderT.H.Wu,Yan-ShenShan*,Szu-YuanWu*.Fucoidaninhibitsradiation-inducedpneumonitisandlungfibrosisbyreducinginflammatorycytokineexpressioninlungtissues.MarDrugs.2018Oct19;16(10)pii:E392.doi:10.3390/md16100392. 36.  Jeffrey.S.Chang;Li-TzongChen;Yan-ShenShan;Pei-YiChu;Chia-RungTsai;Hui-JenTsai.Theincidenceandsurvivalofpancreaticcancerbyhistology,includingraresubtypes:anation-widecancerregistry-basedstudyfromTaiwan.CancerMed.2018Nov;7(11):5775-5788. 37.  Po-LinTseng,Chih-WeiChen,Keng-HsunHu,Hung-ChiCheng,Yuan-HoLin,Wen-HuiTsai,Tain-JunnCheng,Wei-HsuanWu,Chin-WeiYeh,Chin-ChihLin,Hui-JuTsai,Hao-ChunChang,Jiin-HaurChuang,Yan-ShenShan,Wen-TsanChang.Thedecreaseofglycolyticenzymehexokinase1acceleratestumormalignancyviaderegulatingenergymetabolismbutsensitizescancercellsto2-deoxyglucoseinhibition.Oncotarget2018Apr10;9(27):18949-18969.. 38.  HungYP,ChenMH,LinJS,HsiaoCF,ShanYS,ChenYC,ChenLT,LiuTW,LiCP,ChaoY.TheclinicalimpactofthenoveltumormarkerDR-70inunresectablegastriccancerpatients.JChinMedAssoc.2018Jul;81(7):593-598. 39.  LinCY,OuMC,LiuYS,ChuangMT,ShanYS,TsaiHM,WangCK,TsaiYS.ACT-guidedfattransversingcoaxialbiopsytechniqueforpancreaticlesionbiopsythatavoidsmajororgansandvessels.SaudiJGastroenterol.2017;23(6):341-347. 40.  ChenCW,ChengTJ,HoCH,WangJJ,WengSF,HouYC,ChengHC,ChioCC,ShanYS,ChangWT.Increasedriskofbraincancerincidenceinstrokepatients:aclinicalcaseseries,population-basedandlongitudinalfollow-upstudy.Oncotarget.2017Nov15;8(65):108989-108999. 41.  Pei-YiChu*,ShihShengJiang*,Yan-ShenShan*,Wen-ChunHung,Ming-HuangChen,Hui-YouLin,Yu-LinChen,Hui-JenTsai,Li-TzongChen.Mitochondrialphosphoenolpyruvatecarboxykinase(PEPCK-M)regulatesthecellmetabolismofpancreaticneuroendocrinetumors(pNET)andde-sensitizespNETtomTORinhibitors.OncotargetOct9;8(61):103613-103625. 42.  Tsung-MingChang*,Yan-ShenShan*,Pei-YiChu*,ShihShengJiang,Wen-ChunHung,Yu-LinChen,Hsu-ChiTu,Hui-YouLin,Hui-JenTsai,Li-TzongChen.TheregulatoryroleofaberrantPhosphataseandTensinHomologueandLiverKinaseB1onAKT/mTOR/c-Mycaxisinpancreaticneuroendocrinetumors.Oncotarget2017,8(58):98068-83. 43.  Yan-ShenShan,Hui-PingHsu,Ming-DergLai,Yu-HsuanHung,Chih-YangWang,Meng-ChiYen,Yi-LingChen.IncreasedexpressionofcyclinD1correlateswithpoortumordifferentiationandpredictspoorprognosisingastriccancerpatients.OncolLett2017;14:4517-26. 44.  Hao-ChenWang,Chin-WangChen,Chia-LungYang,I-MinTsai,Ya-ChinHou,Chang-JungChen,Yan-ShenShan*.Tumor-AssociatedMacrophagesPromoteEpigeneticSilencingofGelsolinthroughDNAMethyltransferase1inGastricCancerCells.CancerImmunolRes.2017,Oct;5(10):885-897. 45.  GopinathanP,HungLY,WangCH,ChiangNJ,WangYC,ShanYS*,LeeGB*.Automatedselectionofaptamersagainstcholangiocarcinomacellsonanintegratedmicrofluidicplatform.Biomicrofluidics.2017Jul5;11(4):044101. 46.  Shu-TingYen,Chih-JungWang,Shih-FangHuang,Su-ChenHsu,JeremyC.Ying*,Yan-ShenShan*. EffectivenessofTraumaTeamonMedicalResourceUtilizationandQualityofCareforPatientswithMajorTrauma.BMCHealthServicesResearch2017Jul24;17(1):505. 47.  Ching-WenYu,Chien-YuFu,Lien-YuHung,Chih-HungWang,Nai-JungChiang,Yu-ChunWang,Yan-ShenShan*andGwo-BinLee*.ScreeningofPeptideSpecifictoCholangiocarcinomaCancerCellsUsinganIntegratedMicrofluidicSystemandPhageDisplayTechnology.MicrofluidNanofluid2017;21:145. 48.  Lien-YuHung,Nai-JungChiang,Wei-ChunTsai,Chien-YuFu,Yu-ChunWang,Yan-ShenShan*,andGwo-BinLee*.Amicrofluidicchipfordetectingcholangiocarcinomacellsinhumanbile.SciRep2017Jun26;7(1):4248. 49.  IwashitaY,HibiT,OhyamaT,HondaG,YoshidaM,MiuraF,TakadaT,HanHS,HwangTL,ShinyaS,SuzukiK,UmezawaA,YoonYS,ChoiIS,HuangWS,ChenKH,WatanabeM,AbeY,MisawaT,NagakawaY,YoonDS,JangJY,YuHC,AhnKS,KimSC,SongIS,KimJH,YunSS,ChoiSH,JanYY,ShanYS,KerCG,ChanDC,WuCC,LeeKT,ToyotaN,HiguchiR,NakamuraY,MizuguchiY,TakedaY,ItoM,NorimizuS,YamadaS,MatsumuraN,ShindohJ,SunagawaH,GochoT,HasegawaH,RikiyamaT,SataN,KanoN,KitanoS,TokumuraH,YamashitaY,WatanabeG,NakagawaK,KimuraT,YamakawaT,WakabayashiG,MoriR,EndoI,MiyazakiM,YamamotoM.Anopportunityindifficulty:Japan-Korea-TaiwanexpertDelphiconsensusonsurgicaldifficultyduringlaparoscopiccholecystectomy.JHepatobiliaryPancreatSci.2017Apr;24(4):191-198. 50.  TzengHT,TsaiCH,YenYT,ChengHC,ChenYC,PuSW,WangYS,ShanYS,TsengYL,SuWC,LaiWW,WuLW,WangYC.DysregulationofRab37-MediatedCross-talkbetweenCancerCellsandEndothelialCellsviaThrombospondin-1PromotesTumorNeovasculatureandMetastasis.ClinCancerRes.2017May1;23(9):2335-2345. 51.  HibiT,IwashitaY,OhyamaT,HondaG,AbeY,YoshidaM,MiuraF,TakadaT,HanHS,YoonYS,HwangTL,ShinyaS,SuzukiK,UmezawaA,ChoiIS,HuangWS,ChenKH,WatanabeM,MisawaT,NagakawaY,YoonDS,JangJY,YuHC,AhnKS,KimSC,SongIS,KimJH,YunSS,ChoiSH,JanYY,Sheen-ChenSM,ShanYS,KerCG,ChanDC,LeeKT,ToyotaN,HiguchiR,YamamotoM,NakamuraY,MizuguchiY,TakedaY,ItoM,NorimizuS,YamadaS,MatsumuraN,TokumuraH,ShindohJ,SunagawaH,HasegawaH,RikiyamaT,SataN,KanoN,KitanoS,YamashitaY,WatanabeG,NakagawaK,KimuraT,YamakawaT,WakabayashiG,EndoI,MiyazakiM.The"right"wayisnotalwayspopular:Comparisonofsurgeons'perceptionsduringlaparoscopiccholecystectomyforacutecholecystitisamongexpertsfromJapan,Korea,andTaiwan.JHepatobiliaryPancreatSci.2017Jan;24(1):24-32. 52.  Po-HsienHuang,,Pei-JungLu,Li-YunDing,Po-ChenChu,Chih-ChiehTsao,Wei-YuHsu,Bo-HengChen,Pei-RongGu,Chung-TaLi,OSU-NCKUpancreaticcancerstudygroup,SallyE.Henderson,Samuel,K.Kulp,Yan-ShenShan*,Ching-ShihChen*.TGFβpromotesmesenchymalphenotypeofpancreaticcancercells,inpart,throughepigeneticactivationofVAV1.Oncogene2017Apr20;36(16):2202-2214. 53.  Tze-SianChan,Chung-ChiHsu,Kok-TongTan,Wen-YingLiao,Shu-ChingHsu,VincentPai,Wei-YuChen,Yan-ShenShan,Shenq-ShyangHuang,Kuan-YingJiang,Chi-RongLi,MichaelLee,Gi-ShihLien,ValerieWeaver,andKelvinTsai.MetronomicChemotherapyPreventsTherapy-inducedStromalELR+-chemokineParacrineSignalingforTumor-initiatingCells.JEM2016Dec12;213(13):2967-2988. 54.  IwashitaY,OhyamaT,HondaG,HibiT,AbeY,YoshidaM,MiuraF,TakadaT,HanHS,YoonYS,HwangTL,ShinyaS,SuzukiK,UmezawaA,ChoiIS,HuangWS,ChenKH,WatanabeM,MisawaT,NagakawaY,YoonDS,JangJY,YuHC,AhnKS,KimSC,SongIS,KimJH,YunSS,ChoiSH,JanYY,Sheen-ChenSM,ShanYS,KerCG,ChanDC,LeeKT,ToyotaN,HiguchiR,YamamotoM,NakamuraY,MizuguchiY,TakedaY,ItoM,NorimizuS,YamadaS,MatsumuraN,TokumuraH,ShindohJ,SunagawaH,HasegawaH,RikiyamaT,SataN,KanoN,KitanoS,YamashitaY,WatanabeG,NakagawaK,KimuraT,YamakawaT,WakabayashiG,EndoI,MiyazakiM.Whataretheappropriateindicatorsofsurgicaldifficultyduringlaparoscopiccholecystectomy?ResultsfromaJapan-Korea-Taiwanmultinationalsurvey.JHepatobiliaryPancreatSci.2016Sep;23(9):533-47. 55.  PanMR,HsuMC,LuoCW,ChenLT,ShanYS,HungWC.ThehistonemethyltransferaseG9aasatherapeutictargettooverridegemcitabineresistanceinpancreaticcancer.Oncotarget.2016Sep20;7(38):61136-61151. 56.  LiuCT,ChenMH,ChenJS,ChenLT,ShanYS,LuCH,SuYL,KuFC,ChouWC,ChenYY.Theefficacyandsafetyofeverolimusforthetreatmentofprogressivegastroenteropancreaticneuroendocrinetumors:Amulti-institutionobservationalstudyinTaiwan.AsiaPacJClinOncol.2016Dec;12(4):396-402. 57.  HungMC,LaiWW,ChenHH,LeeJC,LinYJ,HsiaoJR,ChengYM,ShanYS,SuWC,WangJD.CosteffectivenessofcancertreatmentinTaiwan.JFormosMedAssoc.2016Aug115(8):609-18. 58.  Nai-JungChiang,Jang-YangChang,Yan-ShenShan*,Li-TzongChen,*.Developingnanoliposomalirinotecan(nal-IRI,MM-398,PEP02)inthemanagementofmetastaticpancreaticcancer.ExpertOpinPharmacother.2016Jul;17(10):1413-20. 59.  TsengPC,ChenCL,ShanYS,LinCF.Anincreaseingalectin-3causescellularunresponsivenesstoIFN-γ-inducedsignaltransductionandgrowthinhibitioningastriccancercells.Oncotarget.2016Mar22;7(12):15150-60. 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