Cre Deleter | Targeting Transgenic Mouse - Taconic Biosciences

Cre Deleter. Ubiquitously active general Cre deleter. This transgene is suspected to be homozygous lethal. Learn More. FindYourModel FindYourModel ModelSearch GEMs TaconicTransgenicModels™EmergingModelsCryopreservedModels StandardStrainsandStocks InbredOutbredHybrid/Congenic StandardImmunodeficients DietInducedMice HumanizedImmuneSystemMice huNOG-EXLModelPortfolioNOGPortfolio TherapeuticAreas&Solutions IBDPortfolioMicrobiomePortfolioNeurosciencePortfolioOncologyImmuno-OncologytADMET™Portfolio 2022PricingGuide DesignYourModel DesignYourModel DesignYourModel KnockoutMice Knock-inModels TransgenicMice KnockdownMice CRISPRGeneEditing ExpressMODEL®EmbryonicStemCell ExpressMODEL®RandomIntegrationTransgenic DrugDevelopment ModelGenerationSolutionsPublications MilestoneReports InquiryForm Taconic-CyagenAlliance BreedYourModel BreedYourModel ColonyManagement AnimalBreedingandHusbandry AnimalModelHousingHealthMonitoringBreedingServicesBackcrossingandSpeedCongenics RederivationandRapidEXPANSION™ MouseandRatRederivationRapidEXPANSION™ CryopreservationandCryorecovery SpermandEmbryoCryopreservationCryorecoveryandFRapid®Expansion ProjectManagement ProjectManagementTeameTACONIC®Platform GenotypingandGeneticAnalysis GenotypingServicesTransgeneCharacterizationGeneExpressionAnalysisGeneticProfiling(SNPTesting) ColonyManagementPublications PrepareYourModel PrepareYourModel PrepareYourModel MicrobiomeSolutionsandGerm-FreeMice Germ-FreeMiceGerm-FreeDerivationsTruBIOME®FecalMicrobiotaTransplantationServiceFecalPelletsandMicrofloraDonorsMicrobiomeResources PreconditioningSolutions SpecialDietAdministrationAnimalAgingSurgicalModelsandServicesRodentID MurineBiospecimenCollection AnimalShippingProducts Taconic-BiomodelsMicrobiomeInitiative Contact searchsite searchsite eTACONIC FindYourModel ModelSearch GEMs TaconicTransgenicModels™EmergingModelsCryopreservedModels StandardStrainsandStocks InbredOutbredHybrid/Congenic StandardImmunodeficients DietInducedMice HumanizedImmuneSystemMice huNOG-EXLModelPortfolioNOGPortfolio TherapeuticAreas&Solutions IBDPortfolioMicrobiomePortfolioNeurosciencePortfolioOncologyImmuno-OncologytADMET™Portfolio 2022PricingGuide DesignYourModel DesignYourModel KnockoutMice Knock-inModels TransgenicMice KnockdownMice CRISPRGeneEditing ExpressMODEL®EmbryonicStemCell ExpressMODEL®RandomIntegrationTransgenic DrugDevelopment ModelGenerationSolutionsPublications MilestoneReports InquiryForm Taconic-CyagenAlliance BreedYourModel ColonyManagement AnimalBreedingandHusbandry AnimalModelHousingHealthMonitoringBreedingServicesBackcrossingandSpeedCongenics RederivationandRapidEXPANSION™ MouseandRatRederivationRapidEXPANSION™ CryopreservationandCryorecovery SpermandEmbryoCryopreservationCryorecoveryandFRapid®Expansion ProjectManagement ProjectManagementTeameTACONIC®Platform GenotypingandGeneticAnalysis GenotypingServicesTransgeneCharacterizationGeneExpressionAnalysisGeneticProfiling(SNPTesting) ColonyManagementPublications PrepareYourModel PrepareYourModel MicrobiomeSolutionsandGerm-FreeMice Germ-FreeMiceGerm-FreeDerivationsTruBIOME®FecalMicrobiotaTransplantationServiceFecalPelletsandMicrofloraDonorsMicrobiomeResources PreconditioningSolutions SpecialDietAdministrationAnimalAgingSurgicalModelsandServicesRodentID MurineBiospecimenCollection AnimalShippingProducts Taconic-BiomodelsMicrobiomeInitiative Contact searchsite searchsite eTACONIC TaconicFindyourmodelGEMsEmergingModelsCreDeleter CreDeleterTargetedTransgenic startanorder| printthispage| sharethispage OrderThisModelOR RequestaQuote CALL:888.822.6642 +4570230405(EUROPE) C57BL/6NTacBackground Model# Genotype Nomenclature 12524-Fki/wtC57BL/6NTac-Gt(ROSA)26Sortm16(cre)Arte 12524-Mki/wtC57BL/6NTac-Gt(ROSA)26Sortm16(cre)Arte ModelDescription UbiquitouslyactivegeneralCredeleter. Thistransgeneissuspectedtobehomozygouslethal. MaternalexpressionofCreoftenleadstodeletionofloxPflankedtargetgenesinCre-negativeembryos. Thismodelreplacesmodel6467.Model12524isfullycongeniconC57BL/6NTac. Ordersbyweight:Taconiccannotacceptordersbyweightforthismodel.Pleasenotethatshipmentsmaycontainanimalswithalargerweightvariation.GeneticBackground:C57BL/6Origin:TheCreDeletermousewasdevelopedbyArtemisPharmaceuticals(nowTaconic).ThemutantwascreatedbyatargetedmutationknockinofCreintotheGt(ROSA)26locus.CreisexpressedunderthecontroloftheGt(ROSA)26Sorgene.Additionalsequenceelementsareadenovirusmajorlatetranscriptspliceacceptorsequencefromtheintron1/exon2boundarysituated5´andFLPrecombinasetarget(FRT)sequences(Saccharomycescerevisiae)situated3´ofCre.TargetingoccurredinC57BL/6NEScells.ThecolonyismaintainedbybreedingheterozygotestowildtypeC57BL/6NTacmice.Color:BlackSpecies:MouseInitialPublication:OttoC,FuchsI,KauselmannG,KernH,ZevnikB,AndreasenP,SchwarzG,AltmannH,KlewerM,SchoorM,VonkR,FritzemeierKH.(2009)GPR30doesnotmediateestrogenicresponsesinreproductiveorgansinmice.BiolReprod80(1):34-41.AnimalDiet:NIH#31MRodentDiet Pricing Selectapricingoption:USDollar Euro 2022PriceTableHealthStandards:EFAfee-bearingagreementisrequiredpriortopurchaseofthisline.Seethelicensingsectionformoreinformation.12524Females12524-FEFki/wtAgeinWeeksQuantity1-9993to10$420.0012524Males12524-MEFki/wtAgeinWeeksQuantity1-9993to10$420.00 2022PriceTableHealthStandards:EFAfee-bearingagreementisrequiredpriortopurchaseofthisline.Seethelicensingsectionformoreinformation.12524Females12524-FEFki/wtAgeinWeeksQuantity1-9993to10€362,0012524Males12524-MEFki/wtAgeinWeeksQuantity1-9993to10€362,00 Licensing AccesstothismodelrequiresexecutionofaCreDeleterCrossbreedingAgreement.Therearetwotypesofagreements,aone-timelicensewhichpermitsasinglecrossbreedingeventtoaspecificmouselineorabroadlicensewhichpermitscrossbreedingtoanunlimitednumberoflinesduringtheterm. ThefeesforaCreDeleterCrossbreedingAgreementthatpermitscrossingoftheCreDeletertoONE(1)specifiedfloxedlineis: $600/€546perlinefornon-profitusers$1,600/€1456perlineforfor-profitusers ThefeesforaCreDeleterCrossbreedingAgreementthatpermitscrossingoftheCreDeletertoanunlimitednumberoflinesduringthetermis: $4,500/€4095peryearfornon-profitusers$12,000/€10920peryearforfor-profitusers Oncetheagreementisexecuted,youmayordermiceforuseincrossbreeding.PleasecontactTaconicCustomerServicefordetails. HealthReport Viewtheproductionlocations(s)andtheaccompanyingcurrentIHMS™HealthReportandTaconicHealthStandardforthismodel Findyourmodel GEMsTaconicTransgenicModels™EmergingModelsCryopreservedModelsStandardStrainsandStocksStandardImmunodeficientsDietInducedMiceHumanizedImmuneSystemMiceTherapeuticAreas&Solutions2022PricingGuide 2022PricingGuideCreateyourcustomPricingGuide RelatedAnimalModels FlpDeleterCreERT2 RelatedServices BreedYourModel RelatedPublications GPR30doesnotmediateestrogenicresponsesinreproductiveorgansinmice.SearchallCreDeleterpublications CustomerService NeedadditionalhelpfindingandorderingTaconicproductsandservices? CONTACTUS 888-TACONIC(822-6642) +4570230405(Europe) Fax:+1(518)697-3910 Close Welcome!Tellusalittleaboutyourself Hereweshowthechatwindow.