Memory retrieval by activating engram cells in mouse models ...

AD: a triple transgenic line obtained by mating c-fos-tTA mice with double transgenic. APP/PS1 mice (Extended Data Fig. 4a–g) and a widely used triple ... %PDF-1.4 %âãÏÓ 20obj <>stream xœí]Ùnå¸}÷WèÌæN hoAò–Ä@ó”ÉL¸ô¼Ìï§(’yu$Qº^ngîû–¹Kµœ*‘ìo7¢ãôu~¸^vÿøzó-ÑDgè&þ‚ˆßn´5ÌrúϦA¸f^Š¾ï;©˜à–ñ@´¡Ó§?}ÝÃiDΔ“¦?lüAŸ~ýåæîyâÉkæuu4¢Ða2šNzÑ=í>=IâÄwÏ?߄ÖÏ?Ýü@ó©?tÏÿ¾Šy;õ@ì™z"šØR³ÞMmj*ÝDsÍ1¯&šhž)#'¢ˆŠõvÞYù ~úH²² ·+~hA2`‰R-ï“FLÞ§–Âćh˜éýúrSo%õaÀ¹ŸRo©·¤W¾ºHîä1O݃EŒD‘ŸZ©Zh•èñî©Ö`ÄQ1·zC¡"d¢QÈ8{6Uç™õÁô%™¼udý¦ïY6™*?n¸Žf› ‰[fU1R8oî[s‰ÊS—}MÐoô…Ü@%C(³ÍM¡$­N@D¾g½´ëŠ'\v %Ñ#m‚þ?Gج]ôiE¦0¥ÖG†5šD³ª¢‡¶Òûñ¹åV0­ú!\SĔ†~÷¤‡¿~픧QƒE‡A^è£eÒ[rZ$ߤ‰æOÿêþ~ó ëÚyâb¾ a+£º¿þñæˏ4ÊO©ño²ináêi"é¥û[8´á´>ðvʦˆÀ%|lkÍ´uaQk-˜UjXâk2=M²Í³!"üãhÊü¦'ëB#*¶Ž/IÔ¼«‘¢ .X8ä$qE-Í~>=‘‹"EËÌÜ X²øR´LÍ¢¬d½/\ EžÉ%? ¼Þ˜ŽéSË¢]Æ1JÓ|Ξ¿è{‡VsŸ˜œExrV%“iHeg¡ñ„I(6ÈæS³ŸG‰zÌ (Lí×M0Š¤yä¡Á¥£%¯ªHsõaÖÕJgh¼f ώžz~ÀšûýâzÞP˜6ù¦È¾ oÂú#ª¥ærw¾¡oXjÐ`wVÞ*ߠã