Hydralazine - Contraindications - Pediatric Oncall

Contraindications : Hypersensitivity to hydralazine; coronary artery disease; mitral valvular rheumatic heart disease are contraindications for its use. Dosing ... SignIn DrugCategories ACEinhibitorAlkylatingagentsAllergiesAlphaagonistsAlphablockersAnalgesicAndrogensAnesthesiaAngiotensin2receptorblockersAntacidAnthelminticsAnti-emeticAnti-epilepticsAnti-goutAnti-thyroidAntiarryhthmicsAntibacterial-TopicalAnticholinergicAnticoagulantsAntidepressants DrugIndex DrugsCategory DrugsAtoZ All A B C D E F G H I J K L M N O P Q R S T U V W X Y Z HydralazineMechanism:Hydralazineisanantihypertensive.Hydralazinelowersbloodpressurebyexertingaperipheralvasodilatingeffectthroughadirectrelaxationofvascularsmoothmuscle.Hydralazine,byalteringcellularcalciummetabolism,interfereswiththecalciummovementswithinthevascularsmoothmusclethatareresponsibleforinitiatingormaintainingthecontractilestate.Indication:ChronichypertensionHypertensivecrisisSevereEssentialHypertensionContraindications:Hypersensitivitytohydralazine;coronaryarterydisease;mitralvalvularrheumaticheartdiseasearecontraindicationsforitsuse.Dosing:HypertensiveCrisis:3months-12months:0.1-0.5mg/kg/dosegivenintravenously3-4timesaday;maximumdoseis2mg/kggivenintravenously4timesaday.Dosesmustbetitratedaccordinglyforbloodpressurecontrol.>12months:0.1-0.2mg/kgIV/IMevery4-6hours.Canincreaseto1.7-3.5mg/kg/dayin4-6divideddoses.Max:20mg/doseor200mg/day.ChronicHypertension:Startwith0.75-1mg/kg/daygivenorally2-4timesaday.For<12months:5mg/kg/daytakenorally2-4timesadayor20mg/doseor200mg/dayasthemaximumdose.For>12months:7.5mg/kg/daytakenorallydividedinto4dailydoses.Max:200mg/day.AdverseEffect:Commonreactions:Fluidretention,headache,peripheralneuritis,tachycardia,palpitation. Rare:Anemia,leukopenia,thrombocytopenia,neutropenia,SLE-likesyndrome. SeriousReactions:Hypersensitivityreaction,anaphylaxis,erythemamultiforme.Interaction:MAOInhibitors:Shouldbeusedwithcautioninpatientsreceivinghydralazine. Diazoxide:Profoundhypotensiveepisodesmayoccur. Beta-blockers(Metoprolol,Propranolol):Serumconcentrationsandpharmacologiceffectsmaybeincreased. NSAIDs:Maydecreasethehemodynamiceffectsofhydralazine;avoiduseifpossibleorcloselymonitorcardiovascularstatus.RenalDose:DoseinRenalImpairmentGFR(mL/min)20-50Startatlowdoseandadjustinaccordancewithresponse10-20Startatlowdoseandadjustinaccordancewithresponse<10StartatlowdoseandadjustinaccordancewithresponseDoseinPatientsundergoingRenalReplacementTherapiesCAPDNotdialysed.DoseasinGFR<10mL/minHDNotdialysed.DoseasinGFR<10mL/minHDF/HighfluxNotdialysed.DoseasinGFR<10mL/minCAV/VVHDNotdialysed.DoseasinGFR=10–20mL/minHepaticDose:Nodosageadjustmentsarerecommended.However,hydralazineundergoesextensivehepaticmetabolism. PediatricOncall 02/05/202217:38:32 02/05/202217:38:32 Hydralazine JoinUs PediatricOncall MedicalCalculators DrugCenter PediatricOncallJournal Parenting VaccineReminder Home AboutUs LinkToUs Terms&Conditions PrivacyPolicy   OnlineOrderingPolicy Sitemap Feedback PartnerSites HIVinChildern VaccineReminder PediatricOncallJournal NewArrival InfectioninChildren-Part3 OtherPediatricOncallBooks PediatricDrugIndex Dengue,Malaria,Leptospirosis&Typhoid InfectioninChildren-Part2 CaseRoundsInPediatricLiverDisorders InfectionInChildren ViewMoreBooks Copyright©2001-2022PediatricOncallAllRightsReserved.Alltrademarksusedarethepropertiesoftheirrespectiveowners. Disclaimer:Theinformationgivenbywww.pediatriconcall.comisprovidedbymedicalandparamedical&Healthprovidersvoluntarilyfordisplay&ismeantonlyforinformationalpurpose.Thesitedoesnotguaranteetheaccuracyorauthenticityoftheinformation.Useofanyinformationissolelyattheuser'sownrisk.TheappearanceofadvertisementorproductinformationinthevarioussectioninthewebsitedoesnotconstituteanendorsementorapprovalbyPediatricOncallofthequalityorvalueofthesaidproductorofclaimsmadebyitsmanufacturer. X SignIn DiseaseA-Z HealthTopics DevelopmentalPediatricsGeneralPediatricsGeneticsImmunodeficienciesInfectiousDiseasesLaboratoryMedicineNeonatologyNutritionPediatricCardiologyPediatricDermatology Viewalltopics  FeaturedArticles PenilehygieneAnaphylaxisAnalitchingHypospadiasUrticaria(hives)andangioedemaCircumcision KidsCorner Drugs&Calculators MedicalCalculators DrugCalculatorsGrowthCalculatorsRenalCalculators ViewallCalculators  DrugIndex ACEinhibitorAlkylatingagentsAllergies ViewallDrugs  PoisoningCenter AluminumphosphideAnti-histaminicsAntidepressants ViewallDrugs  MedicalEqipments MonitorsPumpsIncubators ViewallEqipments  DiagnosticAid Consult&Posts AskaDoctor DiagnosticDilemma QuestionoftheWeek PediatricBlogs SpotDiagnosis GrandRounds PediPoll PediatricOncallJournal CurrentIssue AllIssues AdvanceAccess AbouttheJournal SubmitArticle Books&Apps BookStore PediatricOncall MedicalCalculators VaccineReminder PediatricOncallJournal DrugCenter Parenting CME&Videos UpcomingConferences ConferenceAbstracts MCQs Videos VaccineReminder 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0